| 1 | Sun Sep 13 | at Bengals | W16-13 | 0-0 | .000 | Paycor Stadium · Cincinnati, OH |
| 2 | Sun Sep 20 | vs Chiefs | L20-23 (OT) | 1-1 | .500 | SoFi Stadium · Inglewood, CA |
| 3 | Sun Sep 27 | vs Panthers | L16-21 | 1-2 | .333 | SoFi Stadium · Inglewood, CA |
| 4 | Sun Oct 4 | at Buccaneers | L31-38 | 1-3 | .250 | Raymond James Stadium · Tampa, FL |
| 5 | Mon Oct 12 | at Saints | L27-30 (OT) | 1-4 | .200 | Caesars Superdome · New Orleans, LA |
| 6 | -- BYE WEEK -- |
| 7 | Sun Oct 25 | vs Jaguars | W39-29 | 2-4 | .333 | SoFi Stadium · Inglewood, CA |
| 8 | Sun Nov 1 | at Broncos | L30-31 | 2-5 | .286 | Empower Field at Mile High · Denver, CO |
| 9 | Sun Nov 8 | vs Raiders | L26-31 | 2-6 | .250 | SoFi Stadium · Inglewood, CA |
| 10 | Sun Nov 15 | at Dolphins | L21-29 | 2-7 | .222 | Hard Rock Stadium · Miami Gardens, FL |
| 11 | Sun Nov 22 | vs Jets | W34-28 | 3-7 | .300 | SoFi Stadium · Inglewood, CA |
| 12 | Sun Nov 29 | at Bills | L17-27 | 3-8 | .273 | Highmark Stadium · Orchard Park, NY |
| 13 | Sun Dec 6 | vs Patriots | L0-45 | 3-9 | .250 | SoFi Stadium · Inglewood, CA |
| 14 | Sun Dec 13 | vs Falcons | W20-17 | 4-9 | .308 | SoFi Stadium · Inglewood, CA |
| 15 | Thu Dec 17 | atRaiders | W30-27 (OT) | 5-9 | .357 | Allegiant Stadium · Las Vegas, NV |
| 16 | Sun Dec 27 | vsBroncos | W19-16 | 6-9 | .400 | SoFi Stadium · Inglewood, CA |
| 17 | Sun Jan 3 | atChiefs | W38-21 | 7-9 | .438 | Arrowhead Stadium · Kansas City, MO |
