| 3 | Mon Sep 23 | vs Jaguars | 7:30 PM | 0-2 | .000 | Highmark Stadium · Orchard Park, NY |
| 4 | Sun Sep 29 | at Ravens | 8:20 PM | 0-2 | .000 | M&T Bank Stadium · Baltimore, MD |
| 5 | Sun Oct 6 | at Texans | 1:00 PM | 2-0 | 1.000 | NRG Stadium · Houston, TX |
| 6 | Mon Oct 14 | at Jets | 8:15 PM | 1-1 | .500 | MetLife Stadium · East Rutherford, NJ |
| 7 | Sun Oct 20 | vs Titans | 1:00 PM | 0-2 | .000 | Highmark Stadium · Orchard Park, NY |
| 8 | Sun Oct 27 | at Seahawks | 4:05 PM | 2-0 | 1.000 | Lumen Field · Seattle, WA |
| 9 | Sun Nov 3 | vs Dolphins | 1:00 PM | 1-1 | .500 | Highmark Stadium · Orchard Park, NY |
| 10 | Sun Nov 10 | at Colts | 1:00 PM | 0-2 | .000 | Lucas Oil Stadium · Indianapolis, IN |
| 11 | Sun Nov 17 | vs Chiefs | 4:25 PM | 2-0 | 1.000 | Highmark Stadium · Orchard Park, NY |
| 13 | Sun Dec 1 | vs 49ers | 8:20 PM | 1-1 | .500 | Highmark Stadium · Orchard Park, NY |
| 14 | Sun Dec 8 | at Rams | 4:25 PM | 0-2 | .000 | SoFi Stadium · Inglewood, CA |
| 15 | Sun Dec 15 | at Lions | 4:25 PM | 1-1 | .500 | Ford Field · Detroit, MI |
| 16 | Sun Dec 22 | vs Patriots | 1:00 PM | 1-1 | .500 | Highmark Stadium · Orchard Park, NY |
| 17 | Sun Dec 29 | vsJets | 1:00 PM | 1-1 | .500 | Highmark Stadium · Orchard Park, NY |
| 18 | TBD | atPatriots | TBD | 1-1 | .500 | Gillette Stadium · Foxborough, MA |
Cardinals