| 1 | Sun Sep 8 | at Jets | W17-16 | 1-0 | 1.000 | MetLife Stadium · East Rutherford, NJ |
| 2 | Sun Sep 15 | atGiants | W28-14 | 2-0 | 1.000 | MetLife Stadium · East Rutherford, NJ |
| 3 | Sun Sep 22 | vsBengals | W21-17 | 3-0 | 1.000 | Highmark Stadium · Orchard Park, NY |
| 4 | Sun Sep 29 | vsPatriots | L10-16 | 3-1 | .750 | Highmark Stadium · Orchard Park, NY |
| 5 | Sun Oct 6 | atTitans | W14-7 | 4-1 | .800 | Nissan Stadium · Nashville, TN |
| --bye week-- |
| 7 | Sun Oct 20 | vsDolphins | W31-21 | 5-1 | .833 | Highmark Stadium · Orchard Park, NY |
| 8 | Sun Oct 27 | vsEagles | L13-31 | 5-2 | .714 | Highmark Stadium · Orchard Park, NY |
| 9 | Sun Nov 3 | vsCommanders | W24-9 | 6-2 | .750 | Highmark Stadium · Orchard Park, NY |
| 10 | Sun Nov 10 | atBrowns | L16-19 | 6-3 | .667 | FirstEnergy Stadium · Cleveland, OH |
| 11 | Sun Nov 17 | atDolphins | W37-20 | 7-3 | .700 | Hard Rock Stadium · Miami Gardens, FL |
| 12 | Sun Nov 24 | vsBroncos | W20-3 | 8-3 | .727 | Highmark Stadium · Orchard Park, NY |
| 13 | Thu Nov 28 | atCowboys | W26-15 | 9-3 | .750 | AT&T Stadium · Arlington, TX |
| 14 | Sun Dec 8 | vsRavens | L17-24 | 9-4 | .692 | Highmark Stadium · Orchard Park, NY |
| 15 | Sun Dec 15 | atSteelers | W17-10 | 10-4 | .714 | Acrisure Stadium · Pittsburgh, PA |
| 16 | Sat Dec 21 | atPatriots | L17-24 | 10-5 | .667 | Gillette Stadium · Foxborough, MA |
| 17 | Sun Dec 29 | vsJets | L6-13 | 10-6 | .625 | Highmark Stadium · Orchard Park, NY |
| WC | Sat Jan 4 | atTexans | L19-22 (OT) | 10-6 | .625 | NRG Stadium · Houston, TX |
