| 5 | Sun Oct 5 | vs Patriots | 8:20 PM | 2-2 | .500 | Highmark Stadium · Orchard Park, NY |
| 6 | Mon Oct 13 | atFalcons | 7:15 PM | 2-2 | .500 | Mercedes-Benz Stadium · Atlanta, GA |
| --bye week-- |
| 8 | Sun Oct 26 | atPanthers | 1:00 PM | 1-3 | .250 | Bank of America Stadium · Charlotte, NC |
| 9 | Sun Nov 2 | vsChiefs | 4:25 PM | 2-2 | .500 | Highmark Stadium · Orchard Park, NY |
| 10 | Sun Nov 9 | atDolphins | 1:00 PM | 1-3 | .250 | Hard Rock Stadium · Miami Gardens, FL |
| 11 | Sun Nov 16 | vsBuccaneers | 1:00 PM | 3-1 | .750 | Highmark Stadium · Orchard Park, NY |
| 12 | Thu Nov 20 | atTexans | 8:15 PM | 1-3 | .250 | NRG Stadium · Houston, TX |
| 13 | Sun Nov 30 | atSteelers | 4:25 PM | 3-1 | .750 | Acrisure Stadium · Pittsburgh, PA |
| 14 | Sun Dec 7 | vsBengals | 4:25 PM | 2-2 | .500 | Highmark Stadium · Orchard Park, NY |
| 15 | Sun Dec 14 | atPatriots | 1:00 PM | 2-2 | .500 | Gillette Stadium · Foxborough, MA |
| 16 | Sun Dec 21 | atBrowns | 1:00 PM | 1-3 | .250 | FirstEnergy Stadium · Cleveland, OH |
| 17 | Sun Dec 28 | vsEagles | 4:25 PM | 4-0 | 1.000 | Highmark Stadium · Orchard Park, NY |
| 18 | TBD | vsJets | TBD | 0-4 | .000 | Highmark Stadium · Orchard Park, NY |
