| 3 | Sun Sep 21 | at Giants | 8:20 PM | 0-2 | .000 | MetLife Stadium · East Rutherford, NJ |
| 4 | Sun Sep 28 | vsRavens | 4:25 PM | 1-1 | .500 | Arrowhead Stadium · Kansas City, MO |
| 5 | Mon Oct 6 | atJaguars | 8:15 PM | 1-1 | .500 | TIAA Bank Field · Jacksonville, FL |
| 6 | Sun Oct 12 | vsLions | 8:20 PM | 1-1 | .500 | Arrowhead Stadium · Kansas City, MO |
| 7 | Sun Oct 19 | vsRaiders | 1:00 PM | 1-1 | .500 | Arrowhead Stadium · Kansas City, MO |
| 8 | Mon Oct 27 | vsCommanders | 8:15 PM | 1-1 | .500 | Arrowhead Stadium · Kansas City, MO |
| 9 | Sun Nov 2 | atBills | 4:25 PM | 2-0 | 1.000 | Highmark Stadium · Orchard Park, NY |
| --bye week-- |
| 11 | Sun Nov 16 | atBroncos | 4:25 PM | 1-1 | .500 | Empower Field at Mile High · Denver, CO |
| 12 | Sun Nov 23 | vsColts | 1:00 PM | 2-0 | 1.000 | Arrowhead Stadium · Kansas City, MO |
| 13 | Thu Nov 27 | atCowboys | 4:30 PM | 1-1 | .500 | AT&T Stadium · Arlington, TX |
| 14 | Sun Dec 7 | vsTexans | 8:20 PM | 0-2 | .000 | Arrowhead Stadium · Kansas City, MO |
| 15 | Sun Dec 14 | vsChargers | 1:00 PM | 2-0 | 1.000 | Arrowhead Stadium · Kansas City, MO |
| 16 | Sun Dec 21 | atTitans | 1:00 PM | 0-2 | .000 | Nissan Stadium · Nashville, TN |
| 17 | Thu Dec 25 | vsBroncos | 8:15 PM | 1-1 | .500 | Arrowhead Stadium · Kansas City, MO |
| 18 | TBD | atRaiders | TBD | 1-1 | .500 | Allegiant Stadium · Las Vegas, NV |
