| 1 | Sun Sep 8 | at Jaguars | W40-26 | 1-0 | 1.000 | TIAA Bank Field · Jacksonville, FL |
| 2 | Sun Sep 15 | at Raiders | W28-10 | 2-0 | 1.000 | Allegiant Stadium · Las Vegas, NV |
| 3 | Sun Sep 22 | vs Ravens | W33-28 | 3-0 | 1.000 | Arrowhead Stadium · Kansas City, MO |
| 4 | Sun Sep 29 | at Lions | W34-30 | 4-0 | 1.000 | Ford Field · Detroit, MI |
| 5 | Sun Oct 6 | vs Colts | L13-19 | 4-1 | .800 | Arrowhead Stadium · Kansas City, MO |
| 6 | Sun Oct 13 | vs Texans | L24-31 | 4-2 | .667 | Arrowhead Stadium · Kansas City, MO |
| 7 | Thu Oct 17 | at Broncos | W30-6 | 5-2 | .714 | Empower Field at Mile High · Denver, CO |
| 8 | Sun Oct 27 | vs Packers | L24-31 | 5-3 | .625 | Arrowhead Stadium · Kansas City, MO |
| 9 | Sun Nov 3 | vs Vikings | W26-23 | 6-3 | .667 | Arrowhead Stadium · Kansas City, MO |
| 10 | Sun Nov 10 | at Titans | L32-35 | 6-4 | .600 | Nissan Stadium · Nashville, TN |
| 11 | Mon Nov 18 | at Chargers | W24-17 | 7-4 | .636 | SoFi Stadium · Inglewood, CA |
| 12 | -- BYE WEEK -- |
| 13 | Sun Dec 1 | vsRaiders | W40-9 | 8-4 | .667 | Arrowhead Stadium · Kansas City, MO |
| 14 | Sun Dec 8 | at Patriots | W23-16 | 9-4 | .692 | Gillette Stadium · Foxborough, MA |
| 15 | Sun Dec 15 | vsBroncos | W23-3 | 10-4 | .714 | Arrowhead Stadium · Kansas City, MO |
| 16 | Sun Dec 22 | at Bears | W26-3 | 11-4 | .733 | Soldier Field · Chicago, IL |
| 17 | Sun Dec 29 | vsChargers | W31-21 | 12-4 | .750 | Arrowhead Stadium · Kansas City, MO |
| DIV | Sun Jan 12 | vsTexans | W51-31 | 12-4 | .750 | Arrowhead Stadium · Kansas City, MO |
| CONF | Sun Jan 19 | vsTitans | W35-24 | 12-4 | .750 | Arrowhead Stadium · Kansas City, MO |
| SB | Sun Feb 2 | vs 49ers | W31-20 | 12-4 | .750 | Hard Rock Stadium · Miami Gardens, FL |
