| 1 | Fri Sep 5 | at Chargers | L21-27 | 0-1 | .000 | Arena Corinthians · Sao Paulo, Brazil |
| 2 | Sun Sep 14 | vsEagles | L17-20 | 0-2 | .000 | Arrowhead Stadium · Kansas City, MO |
| 3 | Sun Sep 21 | atGiants | W22-9 | 1-2 | .333 | MetLife Stadium · East Rutherford, NJ |
| 4 | Sun Sep 28 | vsRavens | W37-20 | 2-2 | .500 | Arrowhead Stadium · Kansas City, MO |
| 5 | Mon Oct 6 | atJaguars | L28-31 | 2-3 | .400 | TIAA Bank Field · Jacksonville, FL |
| 6 | Sun Oct 12 | vsLions | W30-17 | 3-3 | .500 | Arrowhead Stadium · Kansas City, MO |
| 7 | Sun Oct 19 | vsRaiders | W31-0 | 4-3 | .571 | Arrowhead Stadium · Kansas City, MO |
| 8 | Mon Oct 27 | vsCommanders | W28-7 | 5-3 | .625 | Arrowhead Stadium · Kansas City, MO |
| 9 | Sun Nov 2 | atBills | L21-28 | 5-4 | .556 | Highmark Stadium · Orchard Park, NY |
| --bye week-- |
| 11 | Sun Nov 16 | atBroncos | L19-22 | 5-5 | .500 | Empower Field at Mile High · Denver, CO |
| 12 | Sun Nov 23 | vsColts | W23-20 (OT) | 6-5 | .545 | Arrowhead Stadium · Kansas City, MO |
| 13 | Thu Nov 27 | atCowboys | L28-31 | 6-6 | .500 | AT&T Stadium · Arlington, TX |
| 14 | Sun Dec 7 | vsTexans | L10-20 | 6-7 | .462 | Arrowhead Stadium · Kansas City, MO |
| 15 | Sun Dec 14 | vsChargers | L13-16 | 6-8 | .429 | Arrowhead Stadium · Kansas City, MO |
| 16 | Sun Dec 21 | atTitans | L9-26 | 6-9 | .400 | Nissan Stadium · Nashville, TN |
| 17 | Thu Dec 25 | vsBroncos | L13-20 | 6-10 | .375 | Arrowhead Stadium · Kansas City, MO |
| 18 | Sun Jan 4 | atRaiders | L12-14 | 6-11 | .353 | Allegiant Stadium · Las Vegas, NV |
