| 1 | Thu Sep 7 | vs Lions | L20-21 | 0-1 | .000 | Arrowhead Stadium · Kansas City, MO |
| 2 | Sun Sep 17 | at Jaguars | W17-9 | 1-1 | .500 | TIAA Bank Field · Jacksonville, FL |
| 3 | Sun Sep 24 | vs Bears | W41-10 | 2-1 | .667 | Arrowhead Stadium · Kansas City, MO |
| 4 | Sun Oct 1 | at Jets | W23-20 | 3-1 | .750 | MetLife Stadium · East Rutherford, NJ |
| 5 | Sun Oct 8 | at Vikings | W27-20 | 4-1 | .800 | U.S. Bank Stadium · Minneapolis, MN |
| 6 | Thu Oct 12 | vs Broncos | W19-8 | 5-1 | .833 | Arrowhead Stadium · Kansas City, MO |
| 7 | Sun Oct 22 | vs Chargers | W31-17 | 6-1 | .857 | Arrowhead Stadium · Kansas City, MO |
| 8 | Sun Oct 29 | atBroncos | L9-24 | 6-2 | .750 | Empower Field at Mile High · Denver, CO |
| 9 | Sun Nov 5 | vs Dolphins | W21-14 | 7-2 | .778 | Arrowhead Stadium · Kansas City, MO |
| 10 | -- BYE WEEK -- |
| 11 | Mon Nov 20 | vs Eagles | L17-21 | 7-3 | .700 | Arrowhead Stadium · Kansas City, MO |
| 12 | Sun Nov 26 | at Raiders | W31-17 | 8-3 | .727 | Allegiant Stadium · Las Vegas, NV |
| 13 | Sun Dec 3 | at Packers | L19-27 | 8-4 | .667 | Lambeau Field · Green Bay, WI |
| 14 | Sun Dec 10 | vs Bills | L17-20 | 8-5 | .615 | Arrowhead Stadium · Kansas City, MO |
| 15 | Sun Dec 17 | at Patriots | W27-17 | 9-5 | .643 | Gillette Stadium · Foxborough, MA |
| 16 | Mon Dec 25 | vsRaiders | L14-20 | 9-6 | .600 | Arrowhead Stadium · Kansas City, MO |
| 17 | Sun Dec 31 | vs Bengals | W25-17 | 10-6 | .625 | Arrowhead Stadium · Kansas City, MO |
| 18 | Sun Jan 7 | atChargers | W13-12 | 11-6 | .647 | SoFi Stadium · Inglewood, CA |
| WC | Sat Jan 13 | vsDolphins | W26-7 | 11-6 | .647 | Arrowhead Stadium · Kansas City, MO |
| DIV | Sun Jan 21 | atBills | W27-24 | 11-6 | .647 | Highmark Stadium · Orchard Park, NY |
| CONF | Sun Jan 28 | at Ravens | W17-10 | 11-6 | .647 | M&T Bank Stadium · Baltimore, MD |
| SB | Sun Feb 11 | vs 49ers | W25-22 (OT) | 11-6 | .647 | Allegiant Stadium · Las Vegas, NV |
