| 1 | Thu Sep 10 | vs Texans | W34-20 | 1-0 | 1.000 | Arrowhead Stadium · Kansas City, MO |
| 2 | Sun Sep 20 | at Chargers | W23-20 (OT) | 2-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 3 | Mon Sep 28 | at Ravens | W34-20 | 3-0 | 1.000 | M&T Bank Stadium · Baltimore, MD |
| 4 | Mon Oct 5 | vs Patriots | W26-10 | 4-0 | 1.000 | Arrowhead Stadium · Kansas City, MO |
| 5 | Sun Oct 11 | vs Raiders | L32-40 | 4-1 | .800 | Arrowhead Stadium · Kansas City, MO |
| 6 | Mon Oct 19 | at Bills | W26-17 | 5-1 | .833 | Highmark Stadium · Orchard Park, NY |
| 7 | Sun Oct 25 | at Broncos | W43-16 | 6-1 | .857 | Empower Field at Mile High · Denver, CO |
| 8 | Sun Nov 1 | vs Jets | W35-9 | 7-1 | .875 | Arrowhead Stadium · Kansas City, MO |
| 9 | Sun Nov 8 | vs Panthers | W33-31 | 8-1 | .889 | Arrowhead Stadium · Kansas City, MO |
| 10 | -- BYE WEEK -- |
| 11 | Sun Nov 22 | atRaiders | W35-31 | 9-1 | .900 | Allegiant Stadium · Las Vegas, NV |
| 12 | Sun Nov 29 | at Buccaneers | W27-24 | 10-1 | .909 | Raymond James Stadium · Tampa, FL |
| 13 | Sun Dec 6 | vsBroncos | W22-16 | 11-1 | .917 | Arrowhead Stadium · Kansas City, MO |
| 14 | Sun Dec 13 | at Dolphins | W33-27 | 12-1 | .923 | Hard Rock Stadium · Miami Gardens, FL |
| 15 | Sun Dec 20 | at Saints | W32-29 | 13-1 | .929 | Caesars Superdome · New Orleans, LA |
| 16 | Sun Dec 27 | vs Falcons | W17-14 | 14-1 | .933 | Arrowhead Stadium · Kansas City, MO |
| 17 | Sun Jan 3 | vsChargers | L21-38 | 14-2 | .875 | Arrowhead Stadium · Kansas City, MO |
| DIV | Sun Jan 17 | vs Browns | W22-17 | 14-2 | .875 | Arrowhead Stadium · Kansas City, MO |
| CONF | Sun Jan 24 | vsBills | W38-24 | 14-2 | .875 | Arrowhead Stadium · Kansas City, MO |
| SB | Sun Feb 7 | atBuccaneers | L9-31 | 14-2 | .875 | Raymond James Stadium · Tampa, FL |
