| 1 | Sun Sep 11 | at Cardinals | W44-21 | 1-0 | 1.000 | State Farm Stadium · Glendale, AZ |
| 2 | Thu Sep 15 | vs Chargers | W27-24 | 2-0 | 1.000 | Arrowhead Stadium · Kansas City, MO |
| 3 | Sun Sep 25 | at Colts | L17-20 | 2-1 | .667 | Lucas Oil Stadium · Indianapolis, IN |
| 4 | Sun Oct 2 | at Buccaneers | W41-31 | 3-1 | .750 | Raymond James Stadium · Tampa, FL |
| 5 | Mon Oct 10 | vs Raiders | W30-29 | 4-1 | .800 | Arrowhead Stadium · Kansas City, MO |
| 6 | Sun Oct 16 | vs Bills | L20-24 | 4-2 | .667 | Arrowhead Stadium · Kansas City, MO |
| 7 | Sun Oct 23 | at 49ers | W44-23 | 5-2 | .714 | Levi's® Stadium · Santa Clara, CA |
| 8 | -- BYE WEEK -- |
| 9 | Sun Nov 6 | vs Titans | W20-17 (OT) | 6-2 | .750 | Arrowhead Stadium · Kansas City, MO |
| 10 | Sun Nov 13 | vs Jaguars | W27-17 | 7-2 | .778 | Arrowhead Stadium · Kansas City, MO |
| 11 | Sun Nov 20 | atChargers | W30-27 | 8-2 | .800 | SoFi Stadium · Inglewood, CA |
| 12 | Sun Nov 27 | vs Rams | W26-10 | 9-2 | .818 | Arrowhead Stadium · Kansas City, MO |
| 13 | Sun Dec 4 | at Bengals | L24-27 | 9-3 | .750 | Paycor Stadium · Cincinnati, OH |
| 14 | Sun Dec 11 | at Broncos | W34-28 | 10-3 | .769 | Empower Field at Mile High · Denver, CO |
| 15 | Sun Dec 18 | at Texans | W30-24 (OT) | 11-3 | .786 | NRG Stadium · Houston, TX |
| 16 | Sat Dec 24 | vs Seahawks | W24-10 | 12-3 | .800 | Arrowhead Stadium · Kansas City, MO |
| 17 | Sun Jan 1 | vsBroncos | W27-24 | 13-3 | .813 | Arrowhead Stadium · Kansas City, MO |
| 18 | Sat Jan 7 | atRaiders | W31-13 | 14-3 | .824 | Allegiant Stadium · Las Vegas, NV |
| DIV | Sat Jan 21 | vsJaguars | W27-20 | 14-3 | .824 | Arrowhead Stadium · Kansas City, MO |
| CONF | Sun Jan 29 | vsBengals | W23-20 | 14-3 | .824 | Arrowhead Stadium · Kansas City, MO |
| SB | Sun Feb 12 | at Eagles | W38-35 | 14-3 | .824 | State Farm Stadium · Glendale, AZ |
