| 1 | Thu Sep 5 | vs Ravens | W27-20 | 1-0 | 1.000 | Arrowhead Stadium · Kansas City, MO |
| 2 | Sun Sep 15 | vsBengals | W26-25 | 2-0 | 1.000 | Arrowhead Stadium · Kansas City, MO |
| 3 | Sun Sep 22 | atFalcons | W22-17 | 3-0 | 1.000 | Mercedes-Benz Stadium · Atlanta, GA |
| 4 | Sun Sep 29 | atChargers | W17-10 | 4-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 5 | Mon Oct 7 | vsSaints | W26-13 | 5-0 | 1.000 | Arrowhead Stadium · Kansas City, MO |
| --bye week-- |
| 7 | Sun Oct 20 | at49ers | W28-18 | 6-0 | 1.000 | Levi's® Stadium · Santa Clara, CA |
| 8 | Sun Oct 27 | atRaiders | W27-20 | 7-0 | 1.000 | Allegiant Stadium · Las Vegas, NV |
| 9 | Mon Nov 4 | vsBuccaneers | W30-24 (OT) | 8-0 | 1.000 | Arrowhead Stadium · Kansas City, MO |
| 10 | Sun Nov 10 | vsBroncos | W16-14 | 9-0 | 1.000 | Arrowhead Stadium · Kansas City, MO |
| 11 | Sun Nov 17 | atBills | L21-30 | 9-1 | .900 | Highmark Stadium · Orchard Park, NY |
| 12 | Sun Nov 24 | atPanthers | W30-27 | 10-1 | .909 | Bank of America Stadium · Charlotte, NC |
| 13 | Fri Nov 29 | vsRaiders | W19-17 | 11-1 | .917 | Arrowhead Stadium · Kansas City, MO |
| 14 | Sun Dec 8 | vsChargers | W19-17 | 12-1 | .923 | Arrowhead Stadium · Kansas City, MO |
| 15 | Sun Dec 15 | atBrowns | W21-7 | 13-1 | .929 | FirstEnergy Stadium · Cleveland, OH |
| 16 | Sat Dec 21 | vsTexans | W27-19 | 14-1 | .933 | Arrowhead Stadium · Kansas City, MO |
| 17 | Wed Dec 25 | atSteelers | W29-10 | 15-1 | .938 | Acrisure Stadium · Pittsburgh, PA |
| 18 | Sun Jan 5 | atBroncos | L0-38 | 15-2 | .882 | Empower Field at Mile High · Denver, CO |
| DIV | Sat Jan 18 | vsTexans | W23-14 | 15-2 | .882 | Arrowhead Stadium · Kansas City, MO |
| CONF | Sun Jan 26 | vsBills | W32-29 | 15-2 | .882 | Arrowhead Stadium · Kansas City, MO |
| SB | Sun Feb 9 | atEagles | L22-40 | 15-2 | .882 | Caesars Superdome · New Orleans, LA |
