| 3 | Sun Sep 22 | vs Chargers | 1:00 PM | 2-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 4 | Sun Sep 29 | at Colts | 1:00 PM | 0-2 | .000 | Lucas Oil Stadium · Indianapolis, IN |
| 5 | Sun Oct 6 | vs Cowboys | 8:20 PM | 1-1 | .500 | Acrisure Stadium · Pittsburgh, PA |
| 6 | Sun Oct 13 | at Raiders | 4:05 PM | 1-1 | .500 | Allegiant Stadium · Las Vegas, NV |
| 7 | Sun Oct 20 | vs Jets | 8:20 PM | 1-1 | .500 | Acrisure Stadium · Pittsburgh, PA |
| 8 | Mon Oct 28 | vs Giants | 8:15 PM | 0-2 | .000 | Acrisure Stadium · Pittsburgh, PA |
| 10 | Sun Nov 10 | at Commanders | 1:00 PM | 1-1 | .500 | FedEx Field · North Englewood, MD |
| 11 | Sun Nov 17 | vs Ravens | 1:00 PM | 0-2 | .000 | Acrisure Stadium · Pittsburgh, PA |
| 12 | Thu Nov 21 | at Browns | 8:15 PM | 1-1 | .500 | FirstEnergy Stadium · Cleveland, OH |
| 13 | Sun Dec 1 | at Bengals | 1:00 PM | 0-2 | .000 | Paycor Stadium · Cincinnati, OH |
| 14 | Sun Dec 8 | vsBrowns | 1:00 PM | 1-1 | .500 | Acrisure Stadium · Pittsburgh, PA |
| 15 | Sun Dec 15 | at Eagles | 4:25 PM | 1-1 | .500 | Lincoln Financial Field · Philadelphia, PA |
| 16 | Sat Dec 21 | atRavens | 4:30 PM | 0-2 | .000 | M&T Bank Stadium · Baltimore, MD |
| 17 | Wed Dec 25 | vs Chiefs | 1:00 PM | 2-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 18 | TBD | vsBengals | TBD | 0-2 | .000 | Acrisure Stadium · Pittsburgh, PA |
Broncos
Falcons