| 1 | Sun Sep 13 | vs Falcons | 1:00 PM | 0-0 | .000 | Acrisure Stadium · Pittsburgh, PA |
| 2 | Sun Sep 20 | atPatriots | 1:00 PM | 0-0 | .000 | Gillette Stadium · Foxborough, MA |
| 3 | Sun Sep 27 | vsBengals | 1:00 PM | 0-0 | .000 | Acrisure Stadium · Pittsburgh, PA |
| 4 | Thu Oct 1 | atBrowns | 8:15 PM | 0-0 | .000 | FirstEnergy Stadium · Cleveland, OH |
| 5 | Sun Oct 11 | vsColts | 1:00 PM | 0-0 | .000 | Acrisure Stadium · Pittsburgh, PA |
| 6 | Sun Oct 18 | atBuccaneers | 1:00 PM | 0-0 | .000 | Raymond James Stadium · Tampa, FL |
| 7 | Sun Oct 25 | atSaints | 9:30 AM | 0-0 | .000 | Caesars Superdome · New Orleans, LA |
| 8 | Sun Nov 1 | vsBrowns | 1:00 PM | 0-0 | .000 | Acrisure Stadium · Pittsburgh, PA |
| --bye week-- |
| 10 | Sun Nov 15 | atBengals | 8:20 PM | 0-0 | .000 | Paycor Stadium · Cincinnati, OH |
| 11 | Sun Nov 22 | atEagles | 4:25 PM | 0-0 | .000 | Lincoln Financial Field · Philadelphia, PA |
| 12 | Fri Nov 27 | vsBroncos | 3:00 PM | 0-0 | .000 | Acrisure Stadium · Pittsburgh, PA |
| 13 | Sun Dec 6 | vsTexans | 8:20 PM | 0-0 | .000 | Acrisure Stadium · Pittsburgh, PA |
| 14 | Mon Dec 14 | atJaguars | 8:15 PM | 0-0 | .000 | TIAA Bank Field · Jacksonville, FL |
| 15 | Sun Dec 20 | vsRavens | 1:00 PM | 0-0 | .000 | Acrisure Stadium · Pittsburgh, PA |
| 16 | TBD | vsPanthers | TBD | 0-0 | .000 | Acrisure Stadium · Pittsburgh, PA |
| 17 | Sun Jan 3 | atTitans | 1:00 PM | 0-0 | .000 | Nissan Stadium · Nashville, TN |
| 18 | TBD | atRavens | TBD | 0-0 | .000 | M&T Bank Stadium · Baltimore, MD |
