| 6 | Sun Oct 12 | vs Browns | 1:00 PM | 1-4 | .200 | Acrisure Stadium · Pittsburgh, PA |
| 7 | Thu Oct 16 | atBengals | 8:15 PM | 2-3 | .400 | Paycor Stadium · Cincinnati, OH |
| 8 | Sun Oct 26 | vsPackers | 8:20 PM | 2-1-1 | .625 | Acrisure Stadium · Pittsburgh, PA |
| 9 | Sun Nov 2 | vsColts | 1:00 PM | 4-1 | .800 | Acrisure Stadium · Pittsburgh, PA |
| 10 | Sun Nov 9 | atChargers | 8:20 PM | 3-2 | .600 | SoFi Stadium · Inglewood, CA |
| 11 | Sun Nov 16 | vsBengals | 1:00 PM | 2-3 | .400 | Acrisure Stadium · Pittsburgh, PA |
| 12 | Sun Nov 23 | atBears | 1:00 PM | 2-2 | .500 | Soldier Field · Chicago, IL |
| 13 | Sun Nov 30 | vsBills | 4:25 PM | 4-1 | .800 | Acrisure Stadium · Pittsburgh, PA |
| 14 | Sun Dec 7 | atRavens | 1:00 PM | 1-4 | .200 | M&T Bank Stadium · Baltimore, MD |
| 15 | Mon Dec 15 | vsDolphins | 8:15 PM | 1-4 | .200 | Acrisure Stadium · Pittsburgh, PA |
| 16 | Sun Dec 21 | atLions | 4:25 PM | 4-1 | .800 | Ford Field · Detroit, MI |
| 17 | Sun Dec 28 | atBrowns | 1:00 PM | 1-4 | .200 | FirstEnergy Stadium · Cleveland, OH |
| 18 | TBD | vsRavens | TBD | 1-4 | .200 | Acrisure Stadium · Pittsburgh, PA |
