| 1 | Sun Sep 8 | at Falcons | W18-10 | 1-0 | 1.000 | Mercedes-Benz Stadium · Atlanta, GA |
| 2 | Sun Sep 15 | at Broncos | W13-6 | 2-0 | 1.000 | Empower Field at Mile High · Denver, CO |
| 3 | Sun Sep 22 | vs Chargers | W20-10 | 3-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 4 | Sun Sep 29 | at Colts | L24-27 | 3-1 | .750 | Lucas Oil Stadium · Indianapolis, IN |
| 5 | Sun Oct 6 | vs Cowboys | L17-20 | 3-2 | .600 | Acrisure Stadium · Pittsburgh, PA |
| 6 | Sun Oct 13 | at Raiders | W32-13 | 4-2 | .667 | Allegiant Stadium · Las Vegas, NV |
| 7 | Sun Oct 20 | vs Jets | W37-15 | 5-2 | .714 | Acrisure Stadium · Pittsburgh, PA |
| 8 | Mon Oct 28 | vs Giants | W26-18 | 6-2 | .750 | Acrisure Stadium · Pittsburgh, PA |
| 9 | -- BYE WEEK -- |
| 10 | Sun Nov 10 | at Commanders | W28-27 | 7-2 | .778 | FedEx Field · North Englewood, MD |
| 11 | Sun Nov 17 | vs Ravens | W18-16 | 8-2 | .800 | Acrisure Stadium · Pittsburgh, PA |
| 12 | Thu Nov 21 | at Browns | L19-24 | 8-3 | .727 | FirstEnergy Stadium · Cleveland, OH |
| 13 | Sun Dec 1 | at Bengals | W44-38 | 9-3 | .750 | Paycor Stadium · Cincinnati, OH |
| 14 | Sun Dec 8 | vsBrowns | W27-14 | 10-3 | .769 | Acrisure Stadium · Pittsburgh, PA |
| 15 | Sun Dec 15 | at Eagles | L13-27 | 10-4 | .714 | Lincoln Financial Field · Philadelphia, PA |
| 16 | Sat Dec 21 | atRavens | L17-34 | 10-5 | .667 | M&T Bank Stadium · Baltimore, MD |
| 17 | Wed Dec 25 | vs Chiefs | L10-29 | 10-6 | .625 | Acrisure Stadium · Pittsburgh, PA |
| 18 | Sat Jan 4 | vsBengals | L17-19 | 10-7 | .588 | Acrisure Stadium · Pittsburgh, PA |
| WC | Sat Jan 11 | atRavens | L14-28 | 10-7 | .588 | M&T Bank Stadium · Baltimore, MD |
