| 3 | Sun Sep 21 | at Patriots | 1:00 PM | 1-1 | .500 | Gillette Stadium · Foxborough, MA |
| 4 | Sun Sep 28 | vsVikings | 9:30 AM | 1-1 | .500 | Acrisure Stadium · Pittsburgh, PA |
| --bye week-- |
| 6 | Sun Oct 12 | vsBrowns | 1:00 PM | 0-2 | .000 | Acrisure Stadium · Pittsburgh, PA |
| 7 | Thu Oct 16 | atBengals | 8:15 PM | 2-0 | 1.000 | Paycor Stadium · Cincinnati, OH |
| 8 | Sun Oct 26 | vsPackers | 8:20 PM | 2-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 9 | Sun Nov 2 | vsColts | 1:00 PM | 2-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 10 | Sun Nov 9 | atChargers | 8:20 PM | 2-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 11 | Sun Nov 16 | vsBengals | 1:00 PM | 2-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 12 | Sun Nov 23 | atBears | 1:00 PM | 0-2 | .000 | Soldier Field · Chicago, IL |
| 13 | Sun Nov 30 | vsBills | 4:25 PM | 2-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 14 | Sun Dec 7 | atRavens | 1:00 PM | 1-1 | .500 | M&T Bank Stadium · Baltimore, MD |
| 15 | Mon Dec 15 | vsDolphins | 8:15 PM | 0-2 | .000 | Acrisure Stadium · Pittsburgh, PA |
| 16 | Sun Dec 21 | atLions | 4:25 PM | 1-1 | .500 | Ford Field · Detroit, MI |
| 17 | Sun Dec 28 | atBrowns | 1:00 PM | 0-2 | .000 | FirstEnergy Stadium · Cleveland, OH |
| 18 | TBD | vsRavens | TBD | 1-1 | .500 | Acrisure Stadium · Pittsburgh, PA |
