| 1 | Sun Sep 10 | vs 49ers | L7-30 | 0-1 | .000 | Acrisure Stadium · Pittsburgh, PA |
| 2 | Mon Sep 18 | vsBrowns | W26-22 | 1-1 | .500 | Acrisure Stadium · Pittsburgh, PA |
| 3 | Sun Sep 24 | atRaiders | W23-18 | 2-1 | .667 | Allegiant Stadium · Las Vegas, NV |
| 4 | Sun Oct 1 | atTexans | L6-30 | 2-2 | .500 | NRG Stadium · Houston, TX |
| 5 | Sun Oct 8 | vsRavens | W17-10 | 3-2 | .600 | Acrisure Stadium · Pittsburgh, PA |
| --bye week-- |
| 7 | Sun Oct 22 | atRams | W24-17 | 4-2 | .667 | SoFi Stadium · Inglewood, CA |
| 8 | Sun Oct 29 | vsJaguars | L10-20 | 4-3 | .571 | Acrisure Stadium · Pittsburgh, PA |
| 9 | Thu Nov 2 | vsTitans | W20-16 | 5-3 | .625 | Acrisure Stadium · Pittsburgh, PA |
| 10 | Sun Nov 12 | vsPackers | W23-19 | 6-3 | .667 | Acrisure Stadium · Pittsburgh, PA |
| 11 | Sun Nov 19 | atBrowns | L10-13 | 6-4 | .600 | FirstEnergy Stadium · Cleveland, OH |
| 12 | Sun Nov 26 | atBengals | W16-10 | 7-4 | .636 | Paycor Stadium · Cincinnati, OH |
| 13 | Sun Dec 3 | vsCardinals | L10-24 | 7-5 | .583 | Acrisure Stadium · Pittsburgh, PA |
| 14 | Thu Dec 7 | vsPatriots | L18-21 | 7-6 | .538 | Acrisure Stadium · Pittsburgh, PA |
| 15 | Sat Dec 16 | atColts | L13-30 | 7-7 | .500 | Lucas Oil Stadium · Indianapolis, IN |
| 16 | Sat Dec 23 | vsBengals | W34-11 | 8-7 | .533 | Acrisure Stadium · Pittsburgh, PA |
| 17 | Sun Dec 31 | atSeahawks | W30-23 | 9-7 | .563 | Lumen Field · Seattle, WA |
| 18 | Sat Jan 6 | atRavens | W17-10 | 10-7 | .588 | M&T Bank Stadium · Baltimore, MD |
| WC | Mon Jan 15 | atBills | L17-31 | 10-7 | .588 | Highmark Stadium · Orchard Park, NY |
