| 1 | Sun Sep 8 | at Patriots | L3-33 | 0-1 | .000 | Gillette Stadium · Foxborough, MA |
| 2 | Sun Sep 15 | vsSeahawks | L26-28 | 0-2 | .000 | Acrisure Stadium · Pittsburgh, PA |
| 3 | Sun Sep 22 | at49ers | L20-24 | 0-3 | .000 | Levi's® Stadium · Santa Clara, CA |
| 4 | Mon Sep 30 | vsBengals | W27-3 | 1-3 | .250 | Acrisure Stadium · Pittsburgh, PA |
| 5 | Sun Oct 6 | vsRavens | L23-26 (OT) | 1-4 | .200 | Acrisure Stadium · Pittsburgh, PA |
| 6 | Sun Oct 13 | atChargers | W24-17 | 2-4 | .333 | SoFi Stadium · Inglewood, CA |
| --bye week-- |
| 8 | Mon Oct 28 | vsDolphins | W27-14 | 3-4 | .429 | Acrisure Stadium · Pittsburgh, PA |
| 9 | Sun Nov 3 | vsColts | W26-24 | 4-4 | .500 | Acrisure Stadium · Pittsburgh, PA |
| 10 | Sun Nov 10 | vsRams | W17-12 | 5-4 | .556 | Acrisure Stadium · Pittsburgh, PA |
| 11 | Thu Nov 14 | atBrowns | L7-21 | 5-5 | .500 | FirstEnergy Stadium · Cleveland, OH |
| 12 | Sun Nov 24 | atBengals | W16-10 | 6-5 | .545 | Paycor Stadium · Cincinnati, OH |
| 13 | Sun Dec 1 | vsBrowns | W20-13 | 7-5 | .583 | Acrisure Stadium · Pittsburgh, PA |
| 14 | Sun Dec 8 | atCardinals | W23-17 | 8-5 | .615 | State Farm Stadium · Glendale, AZ |
| 15 | Sun Dec 15 | vsBills | L10-17 | 8-6 | .571 | Acrisure Stadium · Pittsburgh, PA |
| 16 | Sun Dec 22 | atJets | L10-16 | 8-7 | .533 | MetLife Stadium · East Rutherford, NJ |
| 17 | Sun Dec 29 | atRavens | L10-28 | 8-8 | .500 | M&T Bank Stadium · Baltimore, MD |
