| 1 | Sun Sep 8 | at Lions | L20-26 (OT) | 0-1 | .000 | Ford Field · Detroit, MI |
| 2 | Sun Sep 15 | at Cardinals | L10-41 | 0-2 | .000 | State Farm Stadium · Glendale, AZ |
| 3 | Sun Sep 22 | vs 49ers | W27-24 | 1-2 | .333 | SoFi Stadium · Inglewood, CA |
| 4 | Sun Sep 29 | at Bears | L18-24 | 1-3 | .250 | Soldier Field · Chicago, IL |
| 5 | Sun Oct 6 | vs Packers | L19-24 | 1-4 | .200 | SoFi Stadium · Inglewood, CA |
| 6 | -- BYE WEEK -- |
| 7 | Sun Oct 20 | vs Raiders | W20-15 | 2-4 | .333 | SoFi Stadium · Inglewood, CA |
| 8 | Thu Oct 24 | vs Vikings | W30-20 | 3-4 | .429 | SoFi Stadium · Inglewood, CA |
| 9 | Sun Nov 3 | at Seahawks | W26-20 (OT) | 4-4 | .500 | Lumen Field · Seattle, WA |
| 10 | Mon Nov 11 | vs Dolphins | L15-23 | 4-5 | .444 | SoFi Stadium · Inglewood, CA |
| 11 | Sun Nov 17 | at Patriots | W28-22 | 5-5 | .500 | Gillette Stadium · Foxborough, MA |
| 12 | Sun Nov 24 | vs Eagles | L20-37 | 5-6 | .455 | SoFi Stadium · Inglewood, CA |
| 13 | Sun Dec 1 | at Saints | W21-14 | 6-6 | .500 | Caesars Superdome · New Orleans, LA |
| 14 | Sun Dec 8 | vs Bills | W44-42 | 7-6 | .538 | SoFi Stadium · Inglewood, CA |
| 15 | Thu Dec 12 | at49ers | W12-6 | 8-6 | .571 | Levi's® Stadium · Santa Clara, CA |
| 16 | Sun Dec 22 | at Jets | W19-9 | 9-6 | .600 | MetLife Stadium · East Rutherford, NJ |
| 17 | Sat Dec 28 | vsCardinals | W13-9 | 10-6 | .625 | SoFi Stadium · Inglewood, CA |
| 18 | Sun Jan 5 | vsSeahawks | L25-30 | 10-7 | .588 | SoFi Stadium · Inglewood, CA |
| WC | Mon Jan 13 | vsVikings | W27-9 | 10-7 | .588 | State Farm Stadium · Glendale, AZ |
| DIV | Sun Jan 19 | atEagles | L22-28 | 10-7 | .588 | Lincoln Financial Field · Philadelphia, PA |
