| 3 | Sun Sep 22 | vs 49ers | 4:25 PM | 1-1 | .500 | SoFi Stadium · Inglewood, CA |
| 4 | Sun Sep 29 | at Bears | 1:00 PM | 1-1 | .500 | Soldier Field · Chicago, IL |
| 5 | Sun Oct 6 | vs Packers | 4:25 PM | 1-1 | .500 | SoFi Stadium · Inglewood, CA |
| 7 | Sun Oct 20 | vs Raiders | 4:05 PM | 1-1 | .500 | SoFi Stadium · Inglewood, CA |
| 8 | Thu Oct 24 | vs Vikings | 8:15 PM | 2-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 9 | Sun Nov 3 | at Seahawks | 4:25 PM | 2-0 | 1.000 | Lumen Field · Seattle, WA |
| 10 | Mon Nov 11 | vs Dolphins | 8:15 PM | 1-1 | .500 | SoFi Stadium · Inglewood, CA |
| 11 | Sun Nov 17 | at Patriots | 1:00 PM | 1-1 | .500 | Gillette Stadium · Foxborough, MA |
| 12 | Sun Nov 24 | vs Eagles | 8:20 PM | 1-1 | .500 | SoFi Stadium · Inglewood, CA |
| 13 | Sun Dec 1 | at Saints | 4:05 PM | 2-0 | 1.000 | Caesars Superdome · New Orleans, LA |
| 14 | Sun Dec 8 | vs Bills | 4:25 PM | 2-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 15 | Thu Dec 12 | at49ers | 8:15 PM | 1-1 | .500 | Levi's® Stadium · Santa Clara, CA |
| 16 | Sun Dec 22 | at Jets | 1:00 PM | 1-1 | .500 | MetLife Stadium · East Rutherford, NJ |
| 17 | TBD | vs Cardinals | TBD | 1-1 | .500 | SoFi Stadium · Inglewood, CA |
| 18 | TBD | vsSeahawks | TBD | 2-0 | 1.000 | SoFi Stadium · Inglewood, CA |
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