| 1 | Thu Sep 10 | vs 49ers | 8:35 PM | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 2 | Mon Sep 21 | vsGiants | 8:15 PM | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 3 | Sun Sep 27 | atBroncos | 8:20 PM | 0-0 | .000 | Empower Field at Mile High · Denver, CO |
| 4 | Sun Oct 4 | atEagles | 1:00 PM | 0-0 | .000 | Lincoln Financial Field · Philadelphia, PA |
| 5 | Mon Oct 12 | vsBills | 8:15 PM | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 6 | Sun Oct 18 | vsCardinals | 4:05 PM | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 7 | Sun Oct 25 | atRaiders | 4:25 PM | 0-0 | .000 | Allegiant Stadium · Las Vegas, NV |
| 8 | Sun Nov 1 | vsChargers | 4:05 PM | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 9 | Sun Nov 8 | atCommanders | 1:00 PM | 0-0 | .000 | FedEx Field · North Englewood, MD |
| 10 | Sun Nov 15 | atCardinals | 4:05 PM | 0-0 | .000 | State Farm Stadium · Glendale, AZ |
| --bye week-- |
| 12 | Wed Nov 25 | vsPackers | 8:00 PM | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 13 | Thu Dec 3 | vsChiefs | 8:15 PM | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 14 | Sun Dec 13 | at49ers | 4:25 PM | 0-0 | .000 | Levi's® Stadium · Santa Clara, CA |
| 15 | Sun Dec 20 | vsCowboys | 4:25 PM | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 16 | Fri Dec 25 | atSeahawks | 8:15 PM | 0-0 | .000 | Lumen Field · Seattle, WA |
| 17 | TBD | atBuccaneers | TBD | 0-0 | .000 | Raymond James Stadium · Tampa, FL |
| 18 | TBD | vsSeahawks | TBD | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
