| 1 | Sun Sep 12 | vs Bears | W34-14 | 1-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 2 | Sun Sep 19 | at Colts | W27-24 | 2-0 | 1.000 | Lucas Oil Stadium · Indianapolis, IN |
| 3 | Sun Sep 26 | vs Buccaneers | W34-24 | 3-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 4 | Sun Oct 3 | vs Cardinals | L20-37 | 3-1 | .750 | SoFi Stadium · Inglewood, CA |
| 5 | Thu Oct 7 | at Seahawks | W26-17 | 4-1 | .800 | Lumen Field · Seattle, WA |
| 6 | Sun Oct 17 | at Giants | W38-11 | 5-1 | .833 | MetLife Stadium · East Rutherford, NJ |
| 7 | Sun Oct 24 | vs Lions | W28-19 | 6-1 | .857 | SoFi Stadium · Inglewood, CA |
| 8 | Sun Oct 31 | at Texans | W38-22 | 7-1 | .875 | NRG Stadium · Houston, TX |
| 9 | Sun Nov 7 | vs Titans | L16-28 | 7-2 | .778 | SoFi Stadium · Inglewood, CA |
| 10 | Mon Nov 15 | at 49ers | L10-31 | 7-3 | .700 | Levi's® Stadium · Santa Clara, CA |
| 11 | -- BYE WEEK -- |
| 12 | Sun Nov 28 | at Packers | L28-36 | 7-4 | .636 | Lambeau Field · Green Bay, WI |
| 13 | Sun Dec 5 | vs Jaguars | W37-7 | 8-4 | .667 | SoFi Stadium · Inglewood, CA |
| 14 | Mon Dec 13 | atCardinals | W30-23 | 9-4 | .692 | State Farm Stadium · Glendale, AZ |
| 15 | Tue Dec 21 | vsSeahawks | W20-10 | 10-4 | .714 | SoFi Stadium · Inglewood, CA |
| 16 | Sun Dec 26 | at Vikings | W30-23 | 11-4 | .733 | U.S. Bank Stadium · Minneapolis, MN |
| 17 | Sun Jan 2 | at Ravens | W20-19 | 12-4 | .750 | M&T Bank Stadium · Baltimore, MD |
| 18 | Sun Jan 9 | vs49ers | L24-27 (OT) | 12-5 | .706 | SoFi Stadium · Inglewood, CA |
| WC | Mon Jan 17 | vsCardinals | W34-11 | 12-5 | .706 | SoFi Stadium · Inglewood, CA |
| DIV | Sun Jan 23 | atBuccaneers | W30-27 | 12-5 | .706 | Raymond James Stadium · Tampa, FL |
| CONF | Sun Jan 30 | vs49ers | W20-17 | 12-5 | .706 | SoFi Stadium · Inglewood, CA |
| SB | Sun Feb 13 | at Bengals | W23-20 | 12-5 | .706 | SoFi Stadium · Inglewood, CA |
