| 1 | Thu Sep 8 | vs Bills | L10-31 | 0-1 | .000 | SoFi Stadium · Inglewood, CA |
| 2 | Sun Sep 18 | vsFalcons | W31-27 | 1-1 | .500 | SoFi Stadium · Inglewood, CA |
| 3 | Sun Sep 25 | atCardinals | W20-12 | 2-1 | .667 | State Farm Stadium · Glendale, AZ |
| 4 | Mon Oct 3 | at49ers | L9-24 | 2-2 | .500 | Levi's® Stadium · Santa Clara, CA |
| 5 | Sun Oct 9 | vsCowboys | L10-22 | 2-3 | .400 | SoFi Stadium · Inglewood, CA |
| 6 | Sun Oct 16 | vsPanthers | W24-10 | 3-3 | .500 | SoFi Stadium · Inglewood, CA |
| --bye week-- |
| 8 | Sun Oct 30 | vs49ers | L14-31 | 3-4 | .429 | SoFi Stadium · Inglewood, CA |
| 9 | Sun Nov 6 | atBuccaneers | L13-16 | 3-5 | .375 | Raymond James Stadium · Tampa, FL |
| 10 | Sun Nov 13 | vsCardinals | L17-27 | 3-6 | .333 | SoFi Stadium · Inglewood, CA |
| 11 | Sun Nov 20 | atSaints | L20-27 | 3-7 | .300 | Caesars Superdome · New Orleans, LA |
| 12 | Sun Nov 27 | atChiefs | L10-26 | 3-8 | .273 | Arrowhead Stadium · Kansas City, MO |
| 13 | Sun Dec 4 | vsSeahawks | L23-27 | 3-9 | .250 | SoFi Stadium · Inglewood, CA |
| 14 | Thu Dec 8 | vsRaiders | W17-16 | 4-9 | .308 | SoFi Stadium · Inglewood, CA |
| 15 | Mon Dec 19 | atPackers | L12-24 | 4-10 | .286 | Lambeau Field · Green Bay, WI |
| 16 | Sun Dec 25 | vsBroncos | W51-14 | 5-10 | .333 | SoFi Stadium · Inglewood, CA |
| 17 | Sun Jan 1 | atChargers | L10-31 | 5-11 | .313 | SoFi Stadium · Inglewood, CA |
| 18 | Sun Jan 8 | atSeahawks | L16-19 (OT) | 5-12 | .294 | Lumen Field · Seattle, WA |
