| 1 | Sun Sep 8 | at Panthers | W30-27 | 1-0 | 1.000 | Bank of America Stadium · Charlotte, NC |
| 2 | Sun Sep 15 | vs Saints | W27-9 | 2-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 3 | Sun Sep 22 | at Browns | W20-13 | 3-0 | 1.000 | FirstEnergy Stadium · Cleveland, OH |
| 4 | Sun Sep 29 | vs Buccaneers | L40-55 | 3-1 | .750 | SoFi Stadium · Inglewood, CA |
| 5 | Thu Oct 3 | at Seahawks | L29-30 | 3-2 | .600 | Lumen Field · Seattle, WA |
| 6 | Sun Oct 13 | vs 49ers | L7-20 | 3-3 | .500 | SoFi Stadium · Inglewood, CA |
| 7 | Sun Oct 20 | at Falcons | W37-10 | 4-3 | .571 | Mercedes-Benz Stadium · Atlanta, GA |
| 8 | Sun Oct 27 | vs Bengals | W24-10 | 5-3 | .625 | Wembley Stadium · London, England |
| 9 | -- BYE WEEK -- |
| 10 | Sun Nov 10 | at Steelers | L12-17 | 5-4 | .556 | Acrisure Stadium · Pittsburgh, PA |
| 11 | Sun Nov 17 | vs Bears | W17-7 | 6-4 | .600 | SoFi Stadium · Inglewood, CA |
| 12 | Mon Nov 25 | vs Ravens | L6-45 | 6-5 | .545 | SoFi Stadium · Inglewood, CA |
| 13 | Sun Dec 1 | at Cardinals | W34-7 | 7-5 | .583 | State Farm Stadium · Glendale, AZ |
| 14 | Sun Dec 8 | vsSeahawks | W28-12 | 8-5 | .615 | SoFi Stadium · Inglewood, CA |
| 15 | Sun Dec 15 | at Cowboys | L21-44 | 8-6 | .571 | AT&T Stadium · Arlington, TX |
| 16 | Sat Dec 21 | at49ers | L31-34 | 8-7 | .533 | Levi's® Stadium · Santa Clara, CA |
| 17 | Sun Dec 29 | vsCardinals | W31-24 | 9-7 | .563 | SoFi Stadium · Inglewood, CA |
