| 1 | Sun Sep 13 | vs Cowboys | W20-17 | 1-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 2 | Sun Sep 20 | at Eagles | W37-19 | 2-0 | 1.000 | Lincoln Financial Field · Philadelphia, PA |
| 3 | Sun Sep 27 | at Bills | L32-35 | 2-1 | .667 | Highmark Stadium · Orchard Park, NY |
| 4 | Sun Oct 4 | vs Giants | W17-9 | 3-1 | .750 | SoFi Stadium · Inglewood, CA |
| 5 | Sun Oct 11 | at Commanders | W30-10 | 4-1 | .800 | FedEx Field · North Englewood, MD |
| 6 | Sun Oct 18 | at 49ers | L16-24 | 4-2 | .667 | Levi's® Stadium · Santa Clara, CA |
| 7 | Mon Oct 26 | vs Bears | W24-10 | 5-2 | .714 | SoFi Stadium · Inglewood, CA |
| 8 | Sun Nov 1 | at Dolphins | L17-28 | 5-3 | .625 | Hard Rock Stadium · Miami Gardens, FL |
| 9 | -- BYE WEEK -- |
| 10 | Sun Nov 15 | vs Seahawks | W23-16 | 6-3 | .667 | SoFi Stadium · Inglewood, CA |
| 11 | Mon Nov 23 | at Buccaneers | W27-24 | 7-3 | .700 | Raymond James Stadium · Tampa, FL |
| 12 | Sun Nov 29 | vs49ers | L20-23 | 7-4 | .636 | SoFi Stadium · Inglewood, CA |
| 13 | Sun Dec 6 | at Cardinals | W38-28 | 8-4 | .667 | State Farm Stadium · Glendale, AZ |
| 14 | Thu Dec 10 | vs Patriots | W24-3 | 9-4 | .692 | SoFi Stadium · Inglewood, CA |
| 15 | Sun Dec 20 | vs Jets | L20-23 | 9-5 | .643 | SoFi Stadium · Inglewood, CA |
| 16 | Sun Dec 27 | atSeahawks | L9-20 | 9-6 | .600 | Lumen Field · Seattle, WA |
| 17 | Sun Jan 3 | vsCardinals | W18-7 | 10-6 | .625 | SoFi Stadium · Inglewood, CA |
| WC | Sat Jan 9 | atSeahawks | W30-20 | 10-6 | .625 | Lumen Field · Seattle, WA |
| DIV | Sat Jan 16 | at Packers | L18-32 | 10-6 | .625 | Lambeau Field · Green Bay, WI |
