| 1 | Sun Sep 10 | at Seahawks | W30-13 | 1-0 | 1.000 | Lumen Field · Seattle, WA |
| 2 | Sun Sep 17 | vs49ers | L23-30 | 1-1 | .500 | SoFi Stadium · Inglewood, CA |
| 3 | Mon Sep 25 | atBengals | L16-19 | 1-2 | .333 | Paycor Stadium · Cincinnati, OH |
| 4 | Sun Oct 1 | atColts | W29-23 (OT) | 2-2 | .500 | Lucas Oil Stadium · Indianapolis, IN |
| 5 | Sun Oct 8 | vsEagles | L14-23 | 2-3 | .400 | SoFi Stadium · Inglewood, CA |
| 6 | Sun Oct 15 | vsCardinals | W26-9 | 3-3 | .500 | SoFi Stadium · Inglewood, CA |
| 7 | Sun Oct 22 | vsSteelers | L17-24 | 3-4 | .429 | SoFi Stadium · Inglewood, CA |
| 8 | Sun Oct 29 | atCowboys | L20-43 | 3-5 | .375 | AT&T Stadium · Arlington, TX |
| 9 | Sun Nov 5 | atPackers | L3-20 | 3-6 | .333 | Lambeau Field · Green Bay, WI |
| --bye week-- |
| 11 | Sun Nov 19 | vsSeahawks | W17-16 | 4-6 | .400 | SoFi Stadium · Inglewood, CA |
| 12 | Sun Nov 26 | atCardinals | W37-14 | 5-6 | .455 | State Farm Stadium · Glendale, AZ |
| 13 | Sun Dec 3 | vsBrowns | W36-19 | 6-6 | .500 | SoFi Stadium · Inglewood, CA |
| 14 | Sun Dec 10 | atRavens | L31-37 (OT) | 6-7 | .462 | M&T Bank Stadium · Baltimore, MD |
| 15 | Sun Dec 17 | vsCommanders | W28-20 | 7-7 | .500 | SoFi Stadium · Inglewood, CA |
| 16 | Thu Dec 21 | vsSaints | W30-22 | 8-7 | .533 | SoFi Stadium · Inglewood, CA |
| 17 | Sun Dec 31 | atGiants | W26-25 | 9-7 | .563 | MetLife Stadium · East Rutherford, NJ |
| 18 | Sun Jan 7 | at49ers | W21-20 | 10-7 | .588 | Levi's® Stadium · Santa Clara, CA |
| WC | Sun Jan 14 | atLions | L23-24 | 10-7 | .588 | Ford Field · Detroit, MI |
