| 1 | Sun Sep 7 | vs Texans | W14-9 | 1-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 2 | Sun Sep 14 | atTitans | W33-19 | 2-0 | 1.000 | Nissan Stadium · Nashville, TN |
| 3 | Sun Sep 21 | atEagles | L26-33 | 2-1 | .667 | Lincoln Financial Field · Philadelphia, PA |
| 4 | Sun Sep 28 | vsColts | W27-20 | 3-1 | .750 | SoFi Stadium · Inglewood, CA |
| 5 | Thu Oct 2 | vs49ers | L23-26 (OT) | 3-2 | .600 | SoFi Stadium · Inglewood, CA |
| 6 | Sun Oct 12 | atRavens | W17-3 | 4-2 | .667 | M&T Bank Stadium · Baltimore, MD |
| 7 | Sun Oct 19 | atJaguars | W35-7 | 5-2 | .714 | Wembley Stadium · London, England |
| --bye week-- |
| 9 | Sun Nov 2 | vsSaints | W34-10 | 6-2 | .750 | SoFi Stadium · Inglewood, CA |
| 10 | Sun Nov 9 | at49ers | W42-26 | 7-2 | .778 | Levi's® Stadium · Santa Clara, CA |
| 11 | Sun Nov 16 | vsSeahawks | W21-19 | 8-2 | .800 | SoFi Stadium · Inglewood, CA |
| 12 | Sun Nov 23 | vsBuccaneers | W34-7 | 9-2 | .818 | SoFi Stadium · Inglewood, CA |
| 13 | Sun Nov 30 | atPanthers | L28-31 | 9-3 | .750 | Bank of America Stadium · Charlotte, NC |
| 14 | Sun Dec 7 | atCardinals | W45-17 | 10-3 | .769 | State Farm Stadium · Glendale, AZ |
| 15 | Sun Dec 14 | vsLions | W41-34 | 11-3 | .786 | SoFi Stadium · Inglewood, CA |
| 16 | Thu Dec 18 | atSeahawks | L37-38 (OT) | 11-4 | .733 | Lumen Field · Seattle, WA |
| 17 | Mon Dec 29 | atFalcons | L24-27 | 11-5 | .688 | Mercedes-Benz Stadium · Atlanta, GA |
| 18 | Sun Jan 4 | vsCardinals | W37-20 | 12-5 | .706 | SoFi Stadium · Inglewood, CA |
| WC | Sat Jan 10 | atPanthers | W34-31 | 12-5 | .706 | Bank of America Stadium · Charlotte, NC |
| DIV | Sun Jan 18 | atBears | W20-17 (OT) | 12-5 | .706 | Soldier Field · Chicago, IL |
| CONF | Sun Jan 25 | atSeahawks | L27-31 | 12-5 | .706 | Lumen Field · Seattle, WA |
