| 4 | Sun Sep 28 | vs Colts | 4:05 PM | 3-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 5 | Thu Oct 2 | vs49ers | 8:15 PM | 3-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 6 | Sun Oct 12 | atRavens | 1:00 PM | 1-2 | .333 | M&T Bank Stadium · Baltimore, MD |
| 7 | Sun Oct 19 | atJaguars | 9:30 AM | 2-1 | .667 | Wembley Stadium · London, England |
| --bye week-- |
| 9 | Sun Nov 2 | vsSaints | 4:05 PM | 0-3 | .000 | SoFi Stadium · Inglewood, CA |
| 10 | Sun Nov 9 | at49ers | 4:25 PM | 3-0 | 1.000 | Levi's® Stadium · Santa Clara, CA |
| 11 | Sun Nov 16 | vsSeahawks | 4:05 PM | 3-1 | .750 | SoFi Stadium · Inglewood, CA |
| 12 | Sun Nov 23 | vsBuccaneers | 8:20 PM | 3-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 13 | Sun Nov 30 | atPanthers | 1:00 PM | 1-2 | .333 | Bank of America Stadium · Charlotte, NC |
| 14 | Sun Dec 7 | atCardinals | 4:25 PM | 2-2 | .500 | State Farm Stadium · Glendale, AZ |
| 15 | Sun Dec 14 | vsLions | 4:25 PM | 2-1 | .667 | SoFi Stadium · Inglewood, CA |
| 16 | Thu Dec 18 | atSeahawks | 8:15 PM | 3-1 | .750 | Lumen Field · Seattle, WA |
| 17 | Mon Dec 29 | atFalcons | 8:15 PM | 1-2 | .333 | Mercedes-Benz Stadium · Atlanta, GA |
| 18 | TBD | vsCardinals | TBD | 2-2 | .500 | SoFi Stadium · Inglewood, CA |
