| 1 | Fri Sep 6 | vs Packers | W34-29 | 1-0 | 1.000 | Arena Corinthians · Sao Paulo, Brazil |
| 2 | Mon Sep 16 | vs Falcons | L21-22 | 1-1 | .500 | Lincoln Financial Field · Philadelphia, PA |
| 3 | Sun Sep 22 | at Saints | W15-12 | 2-1 | .667 | Caesars Superdome · New Orleans, LA |
| 4 | Sun Sep 29 | at Buccaneers | L16-33 | 2-2 | .500 | Raymond James Stadium · Tampa, FL |
| 5 | -- BYE WEEK -- |
| 6 | Sun Oct 13 | vs Browns | W20-16 | 3-2 | .600 | Lincoln Financial Field · Philadelphia, PA |
| 7 | Sun Oct 20 | at Giants | W28-3 | 4-2 | .667 | MetLife Stadium · East Rutherford, NJ |
| 8 | Sun Oct 27 | at Bengals | W37-17 | 5-2 | .714 | Paycor Stadium · Cincinnati, OH |
| 9 | Sun Nov 3 | vs Jaguars | W28-23 | 6-2 | .750 | Lincoln Financial Field · Philadelphia, PA |
| 10 | Sun Nov 10 | at Cowboys | W34-6 | 7-2 | .778 | AT&T Stadium · Arlington, TX |
| 11 | Thu Nov 14 | vs Commanders | W26-18 | 8-2 | .800 | Lincoln Financial Field · Philadelphia, PA |
| 12 | Sun Nov 24 | at Rams | W37-20 | 9-2 | .818 | SoFi Stadium · Inglewood, CA |
| 13 | Sun Dec 1 | at Ravens | W24-19 | 10-2 | .833 | M&T Bank Stadium · Baltimore, MD |
| 14 | Sun Dec 8 | vs Panthers | W22-16 | 11-2 | .846 | Lincoln Financial Field · Philadelphia, PA |
| 15 | Sun Dec 15 | vs Steelers | W27-13 | 12-2 | .857 | Lincoln Financial Field · Philadelphia, PA |
| 16 | Sun Dec 22 | atCommanders | L33-36 | 12-3 | .800 | FedEx Field · North Englewood, MD |
| 17 | Sun Dec 29 | vsCowboys | W41-7 | 13-3 | .813 | Lincoln Financial Field · Philadelphia, PA |
| 18 | Sun Jan 5 | vsGiants | W20-13 | 14-3 | .824 | Lincoln Financial Field · Philadelphia, PA |
| WC | Sun Jan 12 | vsPackers | W22-10 | 14-3 | .824 | Lincoln Financial Field · Philadelphia, PA |
| DIV | Sun Jan 19 | vsRams | W28-22 | 14-3 | .824 | Lincoln Financial Field · Philadelphia, PA |
| CONF | Sun Jan 26 | vsCommanders | W55-23 | 14-3 | .824 | Lincoln Financial Field · Philadelphia, PA |
| SB | Sun Feb 9 | vs Chiefs | W40-22 | 14-3 | .824 | Caesars Superdome · New Orleans, LA |
