| 1 | Sun Sep 13 | vs Commanders | 4:25 PM | 0-0 | .000 | Lincoln Financial Field · Philadelphia, PA |
| 2 | Sun Sep 20 | atTitans | 1:00 PM | 0-0 | .000 | Nissan Stadium · Nashville, TN |
| 3 | Mon Sep 28 | atBears | 8:15 PM | 0-0 | .000 | Soldier Field · Chicago, IL |
| 4 | Sun Oct 4 | vsRams | 1:00 PM | 0-0 | .000 | Lincoln Financial Field · Philadelphia, PA |
| 5 | Sun Oct 11 | atJaguars | 9:30 AM | 0-0 | .000 | Tottenham Hotspur Stadium · London, England |
| 6 | Sun Oct 18 | vsPanthers | 1:00 PM | 0-0 | .000 | Lincoln Financial Field · Philadelphia, PA |
| 7 | Mon Oct 26 | vsCowboys | 8:15 PM | 0-0 | .000 | Lincoln Financial Field · Philadelphia, PA |
| 8 | Sun Nov 1 | atCommanders | 8:20 PM | 0-0 | .000 | FedEx Field · North Englewood, MD |
| 9 | Sun Nov 8 | vsGiants | 1:00 PM | 0-0 | .000 | Lincoln Financial Field · Philadelphia, PA |
| --bye week-- |
| 11 | Sun Nov 22 | vsSteelers | 4:25 PM | 0-0 | .000 | Lincoln Financial Field · Philadelphia, PA |
| 12 | Thu Nov 26 | atCowboys | 4:30 PM | 0-0 | .000 | AT&T Stadium · Arlington, TX |
| 13 | Sun Dec 6 | atCardinals | 4:05 PM | 0-0 | .000 | State Farm Stadium · Glendale, AZ |
| 14 | Sun Dec 13 | vsColts | 1:00 PM | 0-0 | .000 | Lincoln Financial Field · Philadelphia, PA |
| 15 | Sat Dec 19 | vsSeahawks | 5:00 PM | 0-0 | .000 | Lincoln Financial Field · Philadelphia, PA |
| 16 | Thu Dec 24 | vsTexans | 8:15 PM | 0-0 | .000 | Lincoln Financial Field · Philadelphia, PA |
| 17 | Sun Jan 3 | at49ers | 8:20 PM | 0-0 | .000 | Levi's® Stadium · Santa Clara, CA |
| 18 | TBD | atGiants | TBD | 0-0 | .000 | MetLife Stadium · East Rutherford, NJ |
