| 1 | Sun Sep 11 | at Lions | W38-35 | 1-0 | 1.000 | Ford Field · Detroit, MI |
| 2 | Mon Sep 19 | vsVikings | W24-7 | 2-0 | 1.000 | Lincoln Financial Field · Philadelphia, PA |
| 3 | Sun Sep 25 | atCommanders | W24-8 | 3-0 | 1.000 | FedEx Field · North Englewood, MD |
| 4 | Sun Oct 2 | vsJaguars | W29-21 | 4-0 | 1.000 | Lincoln Financial Field · Philadelphia, PA |
| 5 | Sun Oct 9 | atCardinals | W20-17 | 5-0 | 1.000 | State Farm Stadium · Glendale, AZ |
| 6 | Sun Oct 16 | vsCowboys | W26-17 | 6-0 | 1.000 | Lincoln Financial Field · Philadelphia, PA |
| --bye week-- |
| 8 | Sun Oct 30 | vsSteelers | W35-13 | 7-0 | 1.000 | Lincoln Financial Field · Philadelphia, PA |
| 9 | Thu Nov 3 | atTexans | W29-17 | 8-0 | 1.000 | NRG Stadium · Houston, TX |
| 10 | Mon Nov 14 | vsCommanders | L21-32 | 8-1 | .889 | Lincoln Financial Field · Philadelphia, PA |
| 11 | Sun Nov 20 | atColts | W17-16 | 9-1 | .900 | Lucas Oil Stadium · Indianapolis, IN |
| 12 | Sun Nov 27 | vsPackers | W40-33 | 10-1 | .909 | Lincoln Financial Field · Philadelphia, PA |
| 13 | Sun Dec 4 | vsTitans | W35-10 | 11-1 | .917 | Lincoln Financial Field · Philadelphia, PA |
| 14 | Sun Dec 11 | atGiants | W48-22 | 12-1 | .923 | MetLife Stadium · East Rutherford, NJ |
| 15 | Sun Dec 18 | atBears | W25-20 | 13-1 | .929 | Soldier Field · Chicago, IL |
| 16 | Sat Dec 24 | atCowboys | L34-40 | 13-2 | .867 | AT&T Stadium · Arlington, TX |
| 17 | Sun Jan 1 | vsSaints | L10-20 | 13-3 | .813 | Lincoln Financial Field · Philadelphia, PA |
| 18 | Sun Jan 8 | vsGiants | W22-16 | 14-3 | .824 | Lincoln Financial Field · Philadelphia, PA |
| DIV | Sat Jan 21 | vsGiants | W38-7 | 14-3 | .824 | Lincoln Financial Field · Philadelphia, PA |
| CONF | Sun Jan 29 | vs49ers | W31-7 | 14-3 | .824 | Lincoln Financial Field · Philadelphia, PA |
| SB | Sun Feb 12 | vsChiefs | L35-38 | 14-3 | .824 | State Farm Stadium · Glendale, AZ |
