| 1 | Sun Sep 13 | at Commanders | L17-27 | 0-1 | .000 | FedEx Field · North Englewood, MD |
| 2 | Sun Sep 20 | vsRams | L19-37 | 0-2 | .000 | Lincoln Financial Field · Philadelphia, PA |
| 3 | Sun Sep 27 | vsBengals | T23-23 (OT) | 0-2-1 | .167 | Lincoln Financial Field · Philadelphia, PA |
| 4 | Sun Oct 4 | at49ers | W25-20 | 1-2-1 | .375 | Levi's® Stadium · Santa Clara, CA |
| 5 | Sun Oct 11 | atSteelers | L29-38 | 1-3-1 | .300 | Acrisure Stadium · Pittsburgh, PA |
| 6 | Sun Oct 18 | vsRavens | L28-30 | 1-4-1 | .250 | Lincoln Financial Field · Philadelphia, PA |
| 7 | Thu Oct 22 | vsGiants | W22-21 | 2-4-1 | .357 | Lincoln Financial Field · Philadelphia, PA |
| 8 | Sun Nov 1 | vsCowboys | W23-9 | 3-4-1 | .438 | Lincoln Financial Field · Philadelphia, PA |
| --bye week-- |
| 10 | Sun Nov 15 | atGiants | L17-27 | 3-5-1 | .389 | MetLife Stadium · East Rutherford, NJ |
| 11 | Sun Nov 22 | atBrowns | L17-22 | 3-6-1 | .350 | FirstEnergy Stadium · Cleveland, OH |
| 12 | Mon Nov 30 | vsSeahawks | L17-23 | 3-7-1 | .318 | Lincoln Financial Field · Philadelphia, PA |
| 13 | Sun Dec 6 | atPackers | L16-30 | 3-8-1 | .292 | Lambeau Field · Green Bay, WI |
| 14 | Sun Dec 13 | vsSaints | W24-21 | 4-8-1 | .346 | Lincoln Financial Field · Philadelphia, PA |
| 15 | Sun Dec 20 | atCardinals | L26-33 | 4-9-1 | .321 | State Farm Stadium · Glendale, AZ |
| 16 | Sun Dec 27 | atCowboys | L17-37 | 4-10-1 | .300 | AT&T Stadium · Arlington, TX |
| 17 | Sun Jan 3 | vsCommanders | L14-20 | 4-11-1 | .281 | Lincoln Financial Field · Philadelphia, PA |
