| 4 | Sun Sep 28 | at Buccaneers | 1:00 PM | 3-0 | 1.000 | Raymond James Stadium · Tampa, FL |
| 5 | Sun Oct 5 | vsBroncos | 1:00 PM | 1-2 | .333 | Lincoln Financial Field · Philadelphia, PA |
| 6 | Thu Oct 9 | atGiants | 8:15 PM | 0-3 | .000 | MetLife Stadium · East Rutherford, NJ |
| 7 | Sun Oct 19 | atVikings | 1:00 PM | 2-1 | .667 | U.S. Bank Stadium · Minneapolis, MN |
| 8 | Sun Oct 26 | vsGiants | 1:00 PM | 0-3 | .000 | Lincoln Financial Field · Philadelphia, PA |
| --bye week-- |
| 10 | Mon Nov 10 | atPackers | 8:15 PM | 2-1 | .667 | Lambeau Field · Green Bay, WI |
| 11 | Sun Nov 16 | vsLions | 8:20 PM | 2-1 | .667 | Lincoln Financial Field · Philadelphia, PA |
| 12 | Sun Nov 23 | atCowboys | 4:25 PM | 1-2 | .333 | AT&T Stadium · Arlington, TX |
| 13 | Fri Nov 28 | vsBears | 3:00 PM | 1-2 | .333 | Lincoln Financial Field · Philadelphia, PA |
| 14 | Mon Dec 8 | atChargers | 8:15 PM | 3-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 15 | Sun Dec 14 | vsRaiders | 1:00 PM | 1-2 | .333 | Lincoln Financial Field · Philadelphia, PA |
| 16 | TBD | atCommanders | TBD | 2-1 | .667 | FedEx Field · North Englewood, MD |
| 17 | Sun Dec 28 | atBills | 4:25 PM | 3-0 | 1.000 | Highmark Stadium · Orchard Park, NY |
| 18 | TBD | vsCommanders | TBD | 2-1 | .667 | Lincoln Financial Field · Philadelphia, PA |
