| 1 | Sun Sep 10 | at Patriots | W25-20 | 1-0 | 1.000 | Gillette Stadium · Foxborough, MA |
| 2 | Thu Sep 14 | vsVikings | W34-28 | 2-0 | 1.000 | Lincoln Financial Field · Philadelphia, PA |
| 3 | Mon Sep 25 | atBuccaneers | W25-11 | 3-0 | 1.000 | Raymond James Stadium · Tampa, FL |
| 4 | Sun Oct 1 | vsCommanders | W34-31 (OT) | 4-0 | 1.000 | Lincoln Financial Field · Philadelphia, PA |
| 5 | Sun Oct 8 | atRams | W23-14 | 5-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 6 | Sun Oct 15 | atJets | L14-20 | 5-1 | .833 | MetLife Stadium · East Rutherford, NJ |
| 7 | Sun Oct 22 | vsDolphins | W31-17 | 6-1 | .857 | Lincoln Financial Field · Philadelphia, PA |
| 8 | Sun Oct 29 | atCommanders | W38-31 | 7-1 | .875 | FedEx Field · North Englewood, MD |
| 9 | Sun Nov 5 | vsCowboys | W28-23 | 8-1 | .889 | Lincoln Financial Field · Philadelphia, PA |
| --bye week-- |
| 11 | Mon Nov 20 | atChiefs | W21-17 | 9-1 | .900 | Arrowhead Stadium · Kansas City, MO |
| 12 | Sun Nov 26 | vsBills | W37-34 (OT) | 10-1 | .909 | Lincoln Financial Field · Philadelphia, PA |
| 13 | Sun Dec 3 | vs49ers | L19-42 | 10-2 | .833 | Lincoln Financial Field · Philadelphia, PA |
| 14 | Sun Dec 10 | atCowboys | L13-33 | 10-3 | .769 | AT&T Stadium · Arlington, TX |
| 15 | Mon Dec 18 | atSeahawks | L17-20 | 10-4 | .714 | Lumen Field · Seattle, WA |
| 16 | Mon Dec 25 | vsGiants | W33-25 | 11-4 | .733 | Lincoln Financial Field · Philadelphia, PA |
| 17 | Sun Dec 31 | vsCardinals | L31-35 | 11-5 | .688 | Lincoln Financial Field · Philadelphia, PA |
| 18 | Sun Jan 7 | atGiants | L10-27 | 11-6 | .647 | MetLife Stadium · East Rutherford, NJ |
| WC | Mon Jan 15 | atBuccaneers | L9-32 | 11-6 | .647 | Raymond James Stadium · Tampa, FL |
