| 1 | Sun Sep 8 | at Giants | W28-6 | 1-0 | 1.000 | MetLife Stadium · East Rutherford, NJ |
| 2 | Sun Sep 15 | vs 49ers | W23-17 | 2-0 | 1.000 | U.S. Bank Stadium · Minneapolis, MN |
| 3 | Sun Sep 22 | vs Texans | W34-7 | 3-0 | 1.000 | U.S. Bank Stadium · Minneapolis, MN |
| 4 | Sun Sep 29 | at Packers | W31-29 | 4-0 | 1.000 | Lambeau Field · Green Bay, WI |
| 5 | Sun Oct 6 | vs Jets | W23-17 | 5-0 | 1.000 | Tottenham Hotspur Stadium · London, England |
| 6 | -- BYE WEEK -- |
| 7 | Sun Oct 20 | vs Lions | L29-31 | 5-1 | .833 | U.S. Bank Stadium · Minneapolis, MN |
| 8 | Thu Oct 24 | at Rams | L20-30 | 5-2 | .714 | SoFi Stadium · Inglewood, CA |
| 9 | Sun Nov 3 | vs Colts | W21-13 | 6-2 | .750 | U.S. Bank Stadium · Minneapolis, MN |
| 10 | Sun Nov 10 | at Jaguars | W12-7 | 7-2 | .778 | TIAA Bank Field · Jacksonville, FL |
| 11 | Sun Nov 17 | at Titans | W23-13 | 8-2 | .800 | Nissan Stadium · Nashville, TN |
| 12 | Sun Nov 24 | at Bears | W30-27 (OT) | 9-2 | .818 | Soldier Field · Chicago, IL |
| 13 | Sun Dec 1 | vs Cardinals | W23-22 | 10-2 | .833 | U.S. Bank Stadium · Minneapolis, MN |
| 14 | Sun Dec 8 | vs Falcons | W42-21 | 11-2 | .846 | U.S. Bank Stadium · Minneapolis, MN |
| 15 | Mon Dec 16 | vsBears | W30-12 | 12-2 | .857 | U.S. Bank Stadium · Minneapolis, MN |
| 16 | Sun Dec 22 | at Seahawks | W27-24 | 13-2 | .867 | Lumen Field · Seattle, WA |
| 17 | Sun Dec 29 | vsPackers | W27-25 | 14-2 | .875 | U.S. Bank Stadium · Minneapolis, MN |
| 18 | Sun Jan 5 | atLions | L9-31 | 14-3 | .824 | Ford Field · Detroit, MI |
| WC | Mon Jan 13 | atRams | L9-27 | 14-3 | .824 | State Farm Stadium · Glendale, AZ |
