| 1 | Sun Sep 10 | vs Buccaneers | L17-20 | 0-1 | .000 | U.S. Bank Stadium · Minneapolis, MN |
| 2 | Thu Sep 14 | at Eagles | L28-34 | 0-2 | .000 | Lincoln Financial Field · Philadelphia, PA |
| 3 | Sun Sep 24 | vs Chargers | L24-28 | 0-3 | .000 | U.S. Bank Stadium · Minneapolis, MN |
| 4 | Sun Oct 1 | at Panthers | W21-13 | 1-3 | .250 | Bank of America Stadium · Charlotte, NC |
| 5 | Sun Oct 8 | vs Chiefs | L20-27 | 1-4 | .200 | U.S. Bank Stadium · Minneapolis, MN |
| 6 | Sun Oct 15 | at Bears | W19-13 | 2-4 | .333 | Soldier Field · Chicago, IL |
| 7 | Mon Oct 23 | vs 49ers | W22-17 | 3-4 | .429 | U.S. Bank Stadium · Minneapolis, MN |
| 8 | Sun Oct 29 | at Packers | W24-10 | 4-4 | .500 | Lambeau Field · Green Bay, WI |
| 9 | Sun Nov 5 | at Falcons | W31-28 | 5-4 | .556 | Mercedes-Benz Stadium · Atlanta, GA |
| 10 | Sun Nov 12 | vs Saints | W27-19 | 6-4 | .600 | U.S. Bank Stadium · Minneapolis, MN |
| 11 | Sun Nov 19 | at Broncos | L20-21 | 6-5 | .545 | Empower Field at Mile High · Denver, CO |
| 12 | Mon Nov 27 | vsBears | L10-12 | 6-6 | .500 | U.S. Bank Stadium · Minneapolis, MN |
| 13 | -- BYE WEEK -- |
| 14 | Sun Dec 10 | at Raiders | W3-0 | 7-6 | .538 | Allegiant Stadium · Las Vegas, NV |
| 15 | Sat Dec 16 | at Bengals | L24-27 (OT) | 7-7 | .500 | Paycor Stadium · Cincinnati, OH |
| 16 | Sun Dec 24 | vs Lions | L24-30 | 7-8 | .467 | U.S. Bank Stadium · Minneapolis, MN |
| 17 | Sun Dec 31 | vsPackers | L10-33 | 7-9 | .438 | U.S. Bank Stadium · Minneapolis, MN |
| 18 | Sun Jan 7 | atLions | L20-30 | 7-10 | .412 | Ford Field · Detroit, MI |
