| 1 | Sun Sep 12 | at Bengals | L24-27 (OT) | - | 0-1 | .000 | Paycor Stadium · Cincinnati, OH |
| 2 | Sun Sep 19 | atCardinals | L33-34 | - | 0-2 | .000 | State Farm Stadium · Glendale, AZ |
| 3 | Sun Sep 26 | vsSeahawks | W30-17 | - | 1-2 | .333 | U.S. Bank Stadium · Minneapolis, MN |
| 4 | Sun Oct 3 | vsBrowns | L7-14 | - | 1-3 | .250 | U.S. Bank Stadium · Minneapolis, MN |
| 5 | Sun Oct 10 | vsLions | W19-17 | - | 2-3 | .400 | U.S. Bank Stadium · Minneapolis, MN |
| 6 | Sun Oct 17 | atPanthers | W34-28 (OT) | - | 3-3 | .500 | Bank of America Stadium · Charlotte, NC |
| --bye week-- |
| 8 | Sun Oct 31 | vsCowboys | L16-20 | - | 3-4 | .429 | U.S. Bank Stadium · Minneapolis, MN |
| 9 | Sun Nov 7 | atRavens | L31-34 (OT) | - | 3-5 | .375 | M&T Bank Stadium · Baltimore, MD |
| 10 | Sun Nov 14 | atChargers | W27-20 | - | 4-5 | .444 | SoFi Stadium · Inglewood, CA |
| 11 | Sun Nov 21 | vsPackers | W34-31 | - | 5-5 | .500 | U.S. Bank Stadium · Minneapolis, MN |
| 12 | Sun Nov 28 | at49ers | L26-34 | - | 5-6 | .455 | Levi's® Stadium · Santa Clara, CA |
| 13 | Sun Dec 5 | atLions | L27-29 | - | 5-7 | .417 | Ford Field · Detroit, MI |
| 14 | Thu Dec 9 | vsSteelers | W36-28 | - | 6-7 | .462 | U.S. Bank Stadium · Minneapolis, MN |
| 15 | Mon Dec 20 | atBears | W17-9 | - | 7-7 | .500 | Soldier Field · Chicago, IL |
| 16 | Sun Dec 26 | vsRams | L23-30 | - | 7-8 | .467 | U.S. Bank Stadium · Minneapolis, MN |
| 17 | Sun Jan 2 | atPackers | L10-37 | - | 7-9 | .438 | Lambeau Field · Green Bay, WI |
| 18 | Sun Jan 9 | vsBears | W31-17 | - | 8-9 | .471 | U.S. Bank Stadium · Minneapolis, MN |
