| 1 | Sun Sep 13 | vs Packers | L34-43 | 0-1 | .000 | U.S. Bank Stadium · Minneapolis, MN |
| 2 | Sun Sep 20 | atColts | L11-28 | 0-2 | .000 | Lucas Oil Stadium · Indianapolis, IN |
| 3 | Sun Sep 27 | vsTitans | L30-31 | 0-3 | .000 | U.S. Bank Stadium · Minneapolis, MN |
| 4 | Sun Oct 4 | atTexans | W31-23 | 1-3 | .250 | NRG Stadium · Houston, TX |
| 5 | Sun Oct 11 | atSeahawks | L26-27 | 1-4 | .200 | Lumen Field · Seattle, WA |
| 6 | Sun Oct 18 | vsFalcons | L23-40 | 1-5 | .167 | U.S. Bank Stadium · Minneapolis, MN |
| --bye week-- |
| 8 | Sun Nov 1 | atPackers | W28-22 | 2-5 | .286 | Lambeau Field · Green Bay, WI |
| 9 | Sun Nov 8 | vsLions | W34-20 | 3-5 | .375 | U.S. Bank Stadium · Minneapolis, MN |
| 10 | Mon Nov 16 | atBears | W19-13 | 4-5 | .444 | Soldier Field · Chicago, IL |
| 11 | Sun Nov 22 | vsCowboys | L28-31 | 4-6 | .400 | U.S. Bank Stadium · Minneapolis, MN |
| 12 | Sun Nov 29 | vsPanthers | W28-27 | 5-6 | .455 | U.S. Bank Stadium · Minneapolis, MN |
| 13 | Sun Dec 6 | vsJaguars | W27-24 (OT) | 6-6 | .500 | U.S. Bank Stadium · Minneapolis, MN |
| 14 | Sun Dec 13 | atBuccaneers | L14-26 | 6-7 | .462 | Raymond James Stadium · Tampa, FL |
| 15 | Sun Dec 20 | vsBears | L27-33 | 6-8 | .429 | U.S. Bank Stadium · Minneapolis, MN |
| 16 | Fri Dec 25 | atSaints | L33-52 | 6-9 | .400 | Caesars Superdome · New Orleans, LA |
| 17 | Sun Jan 3 | atLions | W37-35 | 7-9 | .438 | Ford Field · Detroit, MI |
