| 1 | Sun Sep 11 | vs Packers | W23-7 | 1-0 | 1.000 | U.S. Bank Stadium · Minneapolis, MN |
| 2 | Mon Sep 19 | atEagles | L7-24 | 1-1 | .500 | Lincoln Financial Field · Philadelphia, PA |
| 3 | Sun Sep 25 | vsLions | W28-24 | 2-1 | .667 | U.S. Bank Stadium · Minneapolis, MN |
| 4 | Sun Oct 2 | atSaints | W28-25 | 3-1 | .750 | Tottenham Hotspur Stadium · London, England |
| 5 | Sun Oct 9 | vsBears | W29-22 | 4-1 | .800 | U.S. Bank Stadium · Minneapolis, MN |
| 6 | Sun Oct 16 | atDolphins | W24-16 | 5-1 | .833 | Hard Rock Stadium · Miami Gardens, FL |
| --bye week-- |
| 8 | Sun Oct 30 | vsCardinals | W34-26 | 6-1 | .857 | U.S. Bank Stadium · Minneapolis, MN |
| 9 | Sun Nov 6 | atCommanders | W20-17 | 7-1 | .875 | FedEx Field · North Englewood, MD |
| 10 | Sun Nov 13 | atBills | W33-30 (OT) | 8-1 | .889 | Highmark Stadium · Orchard Park, NY |
| 11 | Sun Nov 20 | vsCowboys | L3-40 | 8-2 | .800 | U.S. Bank Stadium · Minneapolis, MN |
| 12 | Thu Nov 24 | vsPatriots | W33-26 | 9-2 | .818 | U.S. Bank Stadium · Minneapolis, MN |
| 13 | Sun Dec 4 | vsJets | W27-22 | 10-2 | .833 | U.S. Bank Stadium · Minneapolis, MN |
| 14 | Sun Dec 11 | atLions | L23-34 | 10-3 | .769 | Ford Field · Detroit, MI |
| 15 | Sat Dec 17 | vsColts | W39-36 (OT) | 11-3 | .786 | U.S. Bank Stadium · Minneapolis, MN |
| 16 | Sat Dec 24 | vsGiants | W27-24 | 12-3 | .800 | U.S. Bank Stadium · Minneapolis, MN |
| 17 | Sun Jan 1 | atPackers | L17-41 | 12-4 | .750 | Lambeau Field · Green Bay, WI |
| 18 | Sun Jan 8 | atBears | W29-13 | 13-4 | .765 | Soldier Field · Chicago, IL |
| WC | Sun Jan 15 | vsGiants | L24-31 | 13-4 | .765 | U.S. Bank Stadium · Minneapolis, MN |
