| 3 | Sun Sep 22 | vs Bears | 1:00 PM | 1-1 | .500 | Lucas Oil Stadium · Indianapolis, IN |
| 4 | Sun Sep 29 | vs Steelers | 1:00 PM | 2-0 | 1.000 | Lucas Oil Stadium · Indianapolis, IN |
| 5 | Sun Oct 6 | at Jaguars | 1:00 PM | 0-2 | .000 | TIAA Bank Field · Jacksonville, FL |
| 6 | Sun Oct 13 | at Titans | 1:00 PM | 0-2 | .000 | Nissan Stadium · Nashville, TN |
| 7 | Sun Oct 20 | vs Dolphins | 1:00 PM | 1-1 | .500 | Lucas Oil Stadium · Indianapolis, IN |
| 8 | Sun Oct 27 | at Texans | 1:00 PM | 2-0 | 1.000 | NRG Stadium · Houston, TX |
| 9 | Sun Nov 3 | at Vikings | 1:00 PM | 2-0 | 1.000 | U.S. Bank Stadium · Minneapolis, MN |
| 10 | Sun Nov 10 | vs Bills | 1:00 PM | 2-0 | 1.000 | Lucas Oil Stadium · Indianapolis, IN |
| 11 | Sun Nov 17 | at Jets | 8:20 PM | 1-1 | .500 | MetLife Stadium · East Rutherford, NJ |
| 12 | Sun Nov 24 | vs Lions | 1:00 PM | 1-1 | .500 | Lucas Oil Stadium · Indianapolis, IN |
| 13 | Sun Dec 1 | at Patriots | 1:00 PM | 1-1 | .500 | Gillette Stadium · Foxborough, MA |
| 15 | Sun Dec 15 | at Broncos | 4:25 PM | 0-2 | .000 | Empower Field at Mile High · Denver, CO |
| 16 | Sun Dec 22 | vsTitans | 1:00 PM | 0-2 | .000 | Lucas Oil Stadium · Indianapolis, IN |
| 17 | TBD | at Giants | TBD | 0-2 | .000 | MetLife Stadium · East Rutherford, NJ |
| 18 | TBD | vsJaguars | TBD | 0-2 | .000 | Lucas Oil Stadium · Indianapolis, IN |
Packers