| 4 | Sun Sep 28 | at Rams | 4:05 PM | 2-1 | .667 | SoFi Stadium · Inglewood, CA |
| 5 | Sun Oct 5 | vsRaiders | 1:00 PM | 1-2 | .333 | Lucas Oil Stadium · Indianapolis, IN |
| 6 | Sun Oct 12 | vsCardinals | 1:00 PM | 2-2 | .500 | Lucas Oil Stadium · Indianapolis, IN |
| 7 | Sun Oct 19 | atChargers | 4:05 PM | 3-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 8 | Sun Oct 26 | vsTitans | 4:25 PM | 0-3 | .000 | Lucas Oil Stadium · Indianapolis, IN |
| 9 | Sun Nov 2 | atSteelers | 1:00 PM | 2-1 | .667 | Acrisure Stadium · Pittsburgh, PA |
| 10 | Sun Nov 9 | vsFalcons | 9:30 AM | 1-2 | .333 | Lucas Oil Stadium · Indianapolis, IN |
| --bye week-- |
| 12 | Sun Nov 23 | atChiefs | 1:00 PM | 1-2 | .333 | Arrowhead Stadium · Kansas City, MO |
| 13 | Sun Nov 30 | vsTexans | 1:00 PM | 0-3 | .000 | Lucas Oil Stadium · Indianapolis, IN |
| 14 | Sun Dec 7 | atJaguars | 1:00 PM | 2-1 | .667 | TIAA Bank Field · Jacksonville, FL |
| 15 | Sun Dec 14 | atSeahawks | 4:25 PM | 3-1 | .750 | Lumen Field · Seattle, WA |
| 16 | Mon Dec 22 | vs49ers | 8:15 PM | 3-0 | 1.000 | Lucas Oil Stadium · Indianapolis, IN |
| 17 | Sun Dec 28 | vsJaguars | 1:00 PM | 2-1 | .667 | Lucas Oil Stadium · Indianapolis, IN |
| 18 | TBD | atTexans | TBD | 0-3 | .000 | NRG Stadium · Houston, TX |
