| 1 | Sun Sep 13 | vs Ravens | 1:00 PM | 0-0 | .000 | Lucas Oil Stadium · Indianapolis, IN |
| 2 | Sun Sep 20 | atChiefs | 8:20 PM | 0-0 | .000 | Arrowhead Stadium · Kansas City, MO |
| 3 | Sun Sep 27 | vsTexans | 1:00 PM | 0-0 | .000 | Lucas Oil Stadium · Indianapolis, IN |
| 4 | Sun Oct 4 | atCommanders | 9:30 AM | 0-0 | .000 | Tottenham Hotspur Stadium · London, England |
| 5 | Sun Oct 11 | atSteelers | 1:00 PM | 0-0 | .000 | Acrisure Stadium · Pittsburgh, PA |
| 6 | Sun Oct 18 | vsTitans | 1:00 PM | 0-0 | .000 | Lucas Oil Stadium · Indianapolis, IN |
| 7 | Sun Oct 25 | atVikings | 1:00 PM | 0-0 | .000 | U.S. Bank Stadium · Minneapolis, MN |
| 8 | Sun Nov 1 | atJaguars | 1:00 PM | 0-0 | .000 | TIAA Bank Field · Jacksonville, FL |
| 9 | Sun Nov 8 | vsCowboys | 1:00 PM | 0-0 | .000 | Lucas Oil Stadium · Indianapolis, IN |
| 10 | Sun Nov 15 | vsDolphins | 1:00 PM | 0-0 | .000 | Lucas Oil Stadium · Indianapolis, IN |
| 11 | Thu Nov 19 | atTexans | 8:15 PM | 0-0 | .000 | NRG Stadium · Houston, TX |
| 12 | Sun Nov 29 | vsGiants | 1:00 PM | 0-0 | .000 | Lucas Oil Stadium · Indianapolis, IN |
| --bye week-- |
| 14 | Sun Dec 13 | atEagles | 1:00 PM | 0-0 | .000 | Lincoln Financial Field · Philadelphia, PA |
| 15 | Sun Dec 20 | atTitans | 1:00 PM | 0-0 | .000 | Nissan Stadium · Nashville, TN |
| 16 | TBD | vsBengals | TBD | 0-0 | .000 | Lucas Oil Stadium · Indianapolis, IN |
| 17 | Sun Jan 3 | atBrowns | 1:00 PM | 0-0 | .000 | FirstEnergy Stadium · Cleveland, OH |
| 18 | TBD | vsJaguars | TBD | 0-0 | .000 | Lucas Oil Stadium · Indianapolis, IN |
