| 3 | Sun Sep 21 | at Buccaneers | 1:00 PM | 2-0 | 1.000 | Raymond James Stadium · Tampa, FL |
| 4 | Mon Sep 29 | atDolphins | 7:15 PM | 0-2 | .000 | Hard Rock Stadium · Miami Gardens, FL |
| 5 | Sun Oct 5 | vsCowboys | 1:00 PM | 1-1 | .500 | MetLife Stadium · East Rutherford, NJ |
| 6 | Sun Oct 12 | vsBroncos | 9:30 AM | 1-1 | .500 | Tottenham Hotspur Stadium · London, England |
| 7 | Sun Oct 19 | vsPanthers | 1:00 PM | 0-2 | .000 | MetLife Stadium · East Rutherford, NJ |
| 8 | Sun Oct 26 | atBengals | 1:00 PM | 2-0 | 1.000 | Paycor Stadium · Cincinnati, OH |
| --bye week-- |
| 10 | Sun Nov 9 | vsBrowns | 1:00 PM | 0-2 | .000 | MetLife Stadium · East Rutherford, NJ |
| 11 | Thu Nov 13 | atPatriots | 8:15 PM | 1-1 | .500 | Gillette Stadium · Foxborough, MA |
| 12 | Sun Nov 23 | atRavens | 1:00 PM | 1-1 | .500 | M&T Bank Stadium · Baltimore, MD |
| 13 | Sun Nov 30 | vsFalcons | 1:00 PM | 1-1 | .500 | MetLife Stadium · East Rutherford, NJ |
| 14 | Sun Dec 7 | vsDolphins | 1:00 PM | 0-2 | .000 | MetLife Stadium · East Rutherford, NJ |
| 15 | Sun Dec 14 | atJaguars | 1:00 PM | 1-1 | .500 | TIAA Bank Field · Jacksonville, FL |
| 16 | Sun Dec 21 | atSaints | 1:00 PM | 0-2 | .000 | Caesars Superdome · New Orleans, LA |
| 17 | Sun Dec 28 | vsPatriots | 1:00 PM | 1-1 | .500 | MetLife Stadium · East Rutherford, NJ |
| 18 | TBD | atBills | TBD | 2-0 | 1.000 | Highmark Stadium · Orchard Park, NY |
