| 1 | Sun Sep 12 | at Panthers | L14-19 | 0-1 | .000 | Bank of America Stadium · Charlotte, NC |
| 2 | Sun Sep 19 | vs Patriots | L6-25 | 0-2 | .000 | MetLife Stadium · East Rutherford, NJ |
| 3 | Sun Sep 26 | at Broncos | L0-26 | 0-3 | .000 | Empower Field at Mile High · Denver, CO |
| 4 | Sun Oct 3 | vs Titans | W27-24 (OT) | 1-3 | .250 | MetLife Stadium · East Rutherford, NJ |
| 5 | Sun Oct 10 | at Falcons | L20-27 | 1-4 | .200 | Tottenham Hotspur Stadium · London, England |
| 6 | -- BYE WEEK -- |
| 7 | Sun Oct 24 | atPatriots | L13-54 | 1-5 | .167 | Gillette Stadium · Foxborough, MA |
| 8 | Sun Oct 31 | vs Bengals | W34-31 | 2-5 | .286 | MetLife Stadium · East Rutherford, NJ |
| 9 | Thu Nov 4 | at Colts | L30-45 | 2-6 | .250 | Lucas Oil Stadium · Indianapolis, IN |
| 10 | Sun Nov 14 | vs Bills | L17-45 | 2-7 | .222 | MetLife Stadium · East Rutherford, NJ |
| 11 | Sun Nov 21 | vs Dolphins | L17-24 | 2-8 | .200 | MetLife Stadium · East Rutherford, NJ |
| 12 | Sun Nov 28 | at Texans | W21-14 | 3-8 | .273 | NRG Stadium · Houston, TX |
| 13 | Sun Dec 5 | vs Eagles | L18-33 | 3-9 | .250 | MetLife Stadium · East Rutherford, NJ |
| 14 | Sun Dec 12 | vs Saints | L9-30 | 3-10 | .231 | MetLife Stadium · East Rutherford, NJ |
| 15 | Sun Dec 19 | atDolphins | L24-31 | 3-11 | .214 | Hard Rock Stadium · Miami Gardens, FL |
| 16 | Sun Dec 26 | vs Jaguars | W26-21 | 4-11 | .267 | MetLife Stadium · East Rutherford, NJ |
| 17 | Sun Jan 2 | vs Buccaneers | L24-28 | 4-12 | .250 | MetLife Stadium · East Rutherford, NJ |
| 18 | Sun Jan 9 | atBills | L10-27 | 4-13 | .235 | Highmark Stadium · Orchard Park, NY |
