| 1 | Mon Sep 9 | at 49ers | L19-32 | 0-1 | .000 | Levi's® Stadium · Santa Clara, CA |
| 2 | Sun Sep 15 | atTitans | W24-17 | 1-1 | .500 | Nissan Stadium · Nashville, TN |
| 3 | Thu Sep 19 | vsPatriots | W24-3 | 2-1 | .667 | MetLife Stadium · East Rutherford, NJ |
| 4 | Sun Sep 29 | vsBroncos | L9-10 | 2-2 | .500 | MetLife Stadium · East Rutherford, NJ |
| 5 | Sun Oct 6 | atVikings | L17-23 | 2-3 | .400 | Tottenham Hotspur Stadium · London, England |
| 6 | Mon Oct 14 | vsBills | L20-23 | 2-4 | .333 | MetLife Stadium · East Rutherford, NJ |
| 7 | Sun Oct 20 | atSteelers | L15-37 | 2-5 | .286 | Acrisure Stadium · Pittsburgh, PA |
| 8 | Sun Oct 27 | atPatriots | L22-25 | 2-6 | .250 | Gillette Stadium · Foxborough, MA |
| 9 | Thu Oct 31 | vsTexans | W21-13 | 3-6 | .333 | MetLife Stadium · East Rutherford, NJ |
| 10 | Sun Nov 10 | atCardinals | L6-31 | 3-7 | .300 | State Farm Stadium · Glendale, AZ |
| 11 | Sun Nov 17 | vsColts | L27-28 | 3-8 | .273 | MetLife Stadium · East Rutherford, NJ |
| --bye week-- |
| 13 | Sun Dec 1 | vsSeahawks | L21-26 | 3-9 | .250 | MetLife Stadium · East Rutherford, NJ |
| 14 | Sun Dec 8 | atDolphins | L26-32 (OT) | 3-10 | .231 | Hard Rock Stadium · Miami Gardens, FL |
| 15 | Sun Dec 15 | atJaguars | W32-25 | 4-10 | .286 | TIAA Bank Field · Jacksonville, FL |
| 16 | Sun Dec 22 | vsRams | L9-19 | 4-11 | .267 | MetLife Stadium · East Rutherford, NJ |
| 17 | Sun Dec 29 | atBills | L14-40 | 4-12 | .250 | Highmark Stadium · Orchard Park, NY |
| 18 | Sun Jan 5 | vsDolphins | W32-20 | 5-12 | .294 | MetLife Stadium · East Rutherford, NJ |
