| 1 | Mon Sep 11 | vs Bills | W22-16 (OT) | 1-0 | 1.000 | MetLife Stadium · East Rutherford, NJ |
| 2 | Sun Sep 17 | at Cowboys | L10-30 | 1-1 | .500 | AT&T Stadium · Arlington, TX |
| 3 | Sun Sep 24 | vs Patriots | L10-15 | 1-2 | .333 | MetLife Stadium · East Rutherford, NJ |
| 4 | Sun Oct 1 | vs Chiefs | L20-23 | 1-3 | .250 | MetLife Stadium · East Rutherford, NJ |
| 5 | Sun Oct 8 | at Broncos | W31-21 | 2-3 | .400 | Empower Field at Mile High · Denver, CO |
| 6 | Sun Oct 15 | vs Eagles | W20-14 | 3-3 | .500 | MetLife Stadium · East Rutherford, NJ |
| 7 | -- BYE WEEK -- |
| 8 | Sun Oct 29 | at Giants | W13-10 (OT) | 4-3 | .571 | MetLife Stadium · East Rutherford, NJ |
| 9 | Mon Nov 6 | vs Chargers | L6-27 | 4-4 | .500 | MetLife Stadium · East Rutherford, NJ |
| 10 | Sun Nov 12 | at Raiders | L12-16 | 4-5 | .444 | Allegiant Stadium · Las Vegas, NV |
| 11 | Sun Nov 19 | atBills | L6-32 | 4-6 | .400 | Highmark Stadium · Orchard Park, NY |
| 12 | Fri Nov 24 | vs Dolphins | L13-34 | 4-7 | .364 | MetLife Stadium · East Rutherford, NJ |
| 13 | Sun Dec 3 | vs Falcons | L8-13 | 4-8 | .333 | MetLife Stadium · East Rutherford, NJ |
| 14 | Sun Dec 10 | vs Texans | W30-6 | 5-8 | .385 | MetLife Stadium · East Rutherford, NJ |
| 15 | Sun Dec 17 | atDolphins | L0-30 | 5-9 | .357 | Hard Rock Stadium · Miami Gardens, FL |
| 16 | Sun Dec 24 | vs Commanders | W30-28 | 6-9 | .400 | MetLife Stadium · East Rutherford, NJ |
| 17 | Thu Dec 28 | at Browns | L20-37 | 6-10 | .375 | FirstEnergy Stadium · Cleveland, OH |
