| 1 | Sun Sep 12 | at Falcons | W32-6 | 1-0 | 1.000 | Mercedes-Benz Stadium · Atlanta, GA |
| 2 | Sun Sep 19 | vs 49ers | L11-17 | 1-1 | .500 | Lincoln Financial Field · Philadelphia, PA |
| 3 | Mon Sep 27 | at Cowboys | L21-41 | 1-2 | .333 | AT&T Stadium · Arlington, TX |
| 4 | Sun Oct 3 | vs Chiefs | L30-42 | 1-3 | .250 | Lincoln Financial Field · Philadelphia, PA |
| 5 | Sun Oct 10 | at Panthers | W21-18 | 2-3 | .400 | Bank of America Stadium · Charlotte, NC |
| 6 | Thu Oct 14 | vs Buccaneers | L22-28 | 2-4 | .333 | Lincoln Financial Field · Philadelphia, PA |
| 7 | Sun Oct 24 | at Raiders | L22-33 | 2-5 | .286 | Allegiant Stadium · Las Vegas, NV |
| 8 | Sun Oct 31 | at Lions | W44-6 | 3-5 | .375 | Ford Field · Detroit, MI |
| 9 | Sun Nov 7 | vs Chargers | L24-27 | 3-6 | .333 | Lincoln Financial Field · Philadelphia, PA |
| 10 | Sun Nov 14 | at Broncos | W30-13 | 4-6 | .400 | Empower Field at Mile High · Denver, CO |
| 11 | Sun Nov 21 | vs Saints | W40-29 | 5-6 | .455 | Lincoln Financial Field · Philadelphia, PA |
| 12 | Sun Nov 28 | at Giants | L7-13 | 5-7 | .417 | MetLife Stadium · East Rutherford, NJ |
| 13 | Sun Dec 5 | at Jets | W33-18 | 6-7 | .462 | MetLife Stadium · East Rutherford, NJ |
| 14 | -- BYE WEEK -- |
| 15 | Tue Dec 21 | vs Commanders | W27-17 | 7-7 | .500 | Lincoln Financial Field · Philadelphia, PA |
| 16 | Sun Dec 26 | vsGiants | W34-10 | 8-7 | .533 | Lincoln Financial Field · Philadelphia, PA |
| 17 | Sun Jan 2 | atCommanders | W20-16 | 9-7 | .563 | FedEx Field · North Englewood, MD |
| 18 | Sat Jan 8 | vsCowboys | L26-51 | 9-8 | .529 | Lincoln Financial Field · Philadelphia, PA |
| WC | Sun Jan 16 | atBuccaneers | L15-31 | 9-8 | .529 | Raymond James Stadium · Tampa, FL |
