| 1 | Sun Sep 11 | at Bengals | W23-20 (OT) | 1-0 | 1.000 | Paycor Stadium · Cincinnati, OH |
| 2 | Sun Sep 18 | vs Patriots | L14-17 | 1-1 | .500 | Acrisure Stadium · Pittsburgh, PA |
| 3 | Thu Sep 22 | at Browns | L17-29 | 1-2 | .333 | FirstEnergy Stadium · Cleveland, OH |
| 4 | Sun Oct 2 | vs Jets | L20-24 | 1-3 | .250 | Acrisure Stadium · Pittsburgh, PA |
| 5 | Sun Oct 9 | at Bills | L3-38 | 1-4 | .200 | Highmark Stadium · Orchard Park, NY |
| 6 | Sun Oct 16 | vs Buccaneers | W20-18 | 2-4 | .333 | Acrisure Stadium · Pittsburgh, PA |
| 7 | Sun Oct 23 | at Dolphins | L10-16 | 2-5 | .286 | Hard Rock Stadium · Miami Gardens, FL |
| 8 | Sun Oct 30 | at Eagles | L13-35 | 2-6 | .250 | Lincoln Financial Field · Philadelphia, PA |
| 9 | -- BYE WEEK -- |
| 10 | Sun Nov 13 | vs Saints | W20-10 | 3-6 | .333 | Acrisure Stadium · Pittsburgh, PA |
| 11 | Sun Nov 20 | vsBengals | L30-37 | 3-7 | .300 | Acrisure Stadium · Pittsburgh, PA |
| 12 | Mon Nov 28 | at Colts | W24-17 | 4-7 | .364 | Lucas Oil Stadium · Indianapolis, IN |
| 13 | Sun Dec 4 | at Falcons | W19-16 | 5-7 | .417 | Mercedes-Benz Stadium · Atlanta, GA |
| 14 | Sun Dec 11 | vs Ravens | L14-16 | 5-8 | .385 | Acrisure Stadium · Pittsburgh, PA |
| 15 | Sun Dec 18 | at Panthers | W24-16 | 6-8 | .429 | Bank of America Stadium · Charlotte, NC |
| 16 | Sat Dec 24 | vs Raiders | W13-10 | 7-8 | .467 | Acrisure Stadium · Pittsburgh, PA |
| 17 | Sun Jan 1 | atRavens | W16-13 | 8-8 | .500 | M&T Bank Stadium · Baltimore, MD |
| 18 | Sun Jan 8 | vsBrowns | W28-14 | 9-8 | .529 | Acrisure Stadium · Pittsburgh, PA |
