| 1 | Sun Sep 12 | at Bills | W23-16 | 1-0 | 1.000 | Highmark Stadium · Orchard Park, NY |
| 2 | Sun Sep 19 | vsRaiders | L17-26 | 1-1 | .500 | Acrisure Stadium · Pittsburgh, PA |
| 3 | Sun Sep 26 | vsBengals | L10-24 | 1-2 | .333 | Acrisure Stadium · Pittsburgh, PA |
| 4 | Sun Oct 3 | atPackers | L17-27 | 1-3 | .250 | Lambeau Field · Green Bay, WI |
| 5 | Sun Oct 10 | vsBroncos | W27-19 | 2-3 | .400 | Acrisure Stadium · Pittsburgh, PA |
| 6 | Sun Oct 17 | vsSeahawks | W23-20 (OT) | 3-3 | .500 | Acrisure Stadium · Pittsburgh, PA |
| --bye week-- |
| 8 | Sun Oct 31 | atBrowns | W15-10 | 4-3 | .571 | FirstEnergy Stadium · Cleveland, OH |
| 9 | Mon Nov 8 | vsBears | W29-27 | 5-3 | .625 | Acrisure Stadium · Pittsburgh, PA |
| 10 | Sun Nov 14 | vsLions | T16-16 (OT) | 5-3-1 | .611 | Acrisure Stadium · Pittsburgh, PA |
| 11 | Sun Nov 21 | atChargers | L37-41 | 5-4-1 | .550 | SoFi Stadium · Inglewood, CA |
| 12 | Sun Nov 28 | atBengals | L10-41 | 5-5-1 | .500 | Paycor Stadium · Cincinnati, OH |
| 13 | Sun Dec 5 | vsRavens | W20-19 | 6-5-1 | .542 | Acrisure Stadium · Pittsburgh, PA |
| 14 | Thu Dec 9 | atVikings | L28-36 | 6-6-1 | .500 | U.S. Bank Stadium · Minneapolis, MN |
| 15 | Sun Dec 19 | vsTitans | W19-13 | 7-6-1 | .536 | Acrisure Stadium · Pittsburgh, PA |
| 16 | Sun Dec 26 | atChiefs | L10-36 | 7-7-1 | .500 | Arrowhead Stadium · Kansas City, MO |
| 17 | Mon Jan 3 | vsBrowns | W26-14 | 8-7-1 | .531 | Acrisure Stadium · Pittsburgh, PA |
| WC | Sun Jan 16 | atChiefs | L21-42 | 9-7-1 | .559 | Arrowhead Stadium · Kansas City, MO |
