| 1 | Sun Sep 12 | at Commanders | W20-16 | 1-0 | 1.000 | FedEx Field · North Englewood, MD |
| 2 | Sun Sep 19 | vsCowboys | L17-20 | 1-1 | .500 | SoFi Stadium · Inglewood, CA |
| 3 | Sun Sep 26 | atChiefs | W30-24 | 2-1 | .667 | Arrowhead Stadium · Kansas City, MO |
| 4 | Mon Oct 4 | vsRaiders | W28-14 | 3-1 | .750 | SoFi Stadium · Inglewood, CA |
| 5 | Sun Oct 10 | vsBrowns | W47-42 | 4-1 | .800 | SoFi Stadium · Inglewood, CA |
| 6 | Sun Oct 17 | atRavens | L6-34 | 4-2 | .667 | M&T Bank Stadium · Baltimore, MD |
| --bye week-- |
| 8 | Sun Oct 31 | vsPatriots | L24-27 | 4-3 | .571 | SoFi Stadium · Inglewood, CA |
| 9 | Sun Nov 7 | atEagles | W27-24 | 5-3 | .625 | Lincoln Financial Field · Philadelphia, PA |
| 10 | Sun Nov 14 | vsVikings | L20-27 | 5-4 | .556 | SoFi Stadium · Inglewood, CA |
| 11 | Sun Nov 21 | vsSteelers | W41-37 | 6-4 | .600 | SoFi Stadium · Inglewood, CA |
| 12 | Sun Nov 28 | atBroncos | L13-28 | 6-5 | .545 | Empower Field at Mile High · Denver, CO |
| 13 | Sun Dec 5 | atBengals | W41-22 | 7-5 | .583 | Paycor Stadium · Cincinnati, OH |
| 14 | Sun Dec 12 | vsGiants | W37-21 | 8-5 | .615 | SoFi Stadium · Inglewood, CA |
| 15 | Thu Dec 16 | vsChiefs | L28-34 (OT) | 8-6 | .571 | SoFi Stadium · Inglewood, CA |
| 16 | Sun Dec 26 | atTexans | L29-41 | 8-7 | .533 | NRG Stadium · Houston, TX |
| 17 | Sun Jan 2 | vsBroncos | W34-13 | 9-7 | .563 | SoFi Stadium · Inglewood, CA |
| 18 | Sun Jan 9 | atRaiders | L32-35 (OT) | 9-8 | .529 | Allegiant Stadium · Las Vegas, NV |
