| 1 | Sun Sep 10 | vs Dolphins | L34-36 | 0-1 | .000 | SoFi Stadium · Inglewood, CA |
| 2 | Sun Sep 17 | at Titans | L24-27 (OT) | 0-2 | .000 | Nissan Stadium · Nashville, TN |
| 3 | Sun Sep 24 | at Vikings | W28-24 | 1-2 | .333 | U.S. Bank Stadium · Minneapolis, MN |
| 4 | Sun Oct 1 | vs Raiders | W24-17 | 2-2 | .500 | SoFi Stadium · Inglewood, CA |
| 5 | -- BYE WEEK -- |
| 6 | Mon Oct 16 | vs Cowboys | L17-20 | 2-3 | .400 | SoFi Stadium · Inglewood, CA |
| 7 | Sun Oct 22 | at Chiefs | L17-31 | 2-4 | .333 | Arrowhead Stadium · Kansas City, MO |
| 8 | Sun Oct 29 | vs Bears | W30-13 | 3-4 | .429 | SoFi Stadium · Inglewood, CA |
| 9 | Mon Nov 6 | at Jets | W27-6 | 4-4 | .500 | MetLife Stadium · East Rutherford, NJ |
| 10 | Sun Nov 12 | vs Lions | L38-41 | 4-5 | .444 | SoFi Stadium · Inglewood, CA |
| 11 | Sun Nov 19 | at Packers | L20-23 | 4-6 | .400 | Lambeau Field · Green Bay, WI |
| 12 | Sun Nov 26 | vs Ravens | L10-20 | 4-7 | .364 | SoFi Stadium · Inglewood, CA |
| 13 | Sun Dec 3 | at Patriots | W6-0 | 5-7 | .417 | Gillette Stadium · Foxborough, MA |
| 14 | Sun Dec 10 | vs Broncos | L7-24 | 5-8 | .385 | SoFi Stadium · Inglewood, CA |
| 15 | Thu Dec 14 | atRaiders | L21-63 | 5-9 | .357 | Allegiant Stadium · Las Vegas, NV |
| 16 | Sat Dec 23 | vs Bills | L22-24 | 5-10 | .333 | SoFi Stadium · Inglewood, CA |
| 17 | Sun Dec 31 | atBroncos | L9-16 | 5-11 | .313 | Empower Field at Mile High · Denver, CO |
| 18 | Sun Jan 7 | vsChiefs | L12-13 | 5-12 | .294 | SoFi Stadium · Inglewood, CA |
