| 1 | Sun Sep 13 | vs Cardinals | L20-24 | 0-0 | .000 | Levi's® Stadium · Santa Clara, CA |
| 2 | Sun Sep 20 | at Jets | W31-13 | 1-1 | .500 | MetLife Stadium · East Rutherford, NJ |
| 3 | Sun Sep 27 | at Giants | W36-9 | 2-1 | .667 | MetLife Stadium · East Rutherford, NJ |
| 4 | Sun Oct 4 | vs Eagles | L20-25 | 2-2 | .500 | Levi's® Stadium · Santa Clara, CA |
| 5 | Sun Oct 11 | vs Dolphins | L17-43 | 2-3 | .400 | Levi's® Stadium · Santa Clara, CA |
| 6 | Sun Oct 18 | vs Rams | W24-16 | 3-3 | .500 | Levi's® Stadium · Santa Clara, CA |
| 7 | Sun Oct 25 | at Patriots | W33-6 | 4-3 | .571 | Gillette Stadium · Foxborough, MA |
| 8 | Sun Nov 1 | at Seahawks | L27-37 | 4-4 | .500 | Lumen Field · Seattle, WA |
| 9 | Thu Nov 5 | vs Packers | L17-34 | 4-5 | .444 | Levi's® Stadium · Santa Clara, CA |
| 10 | Sun Nov 15 | at Saints | L13-27 | 4-6 | .400 | Caesars Superdome · New Orleans, LA |
| 11 | -- BYE WEEK -- |
| 12 | Sun Nov 29 | atRams | W23-20 | 5-6 | .455 | SoFi Stadium · Inglewood, CA |
| 13 | Mon Dec 7 | vs Bills | L24-34 | 5-7 | .417 | State Farm Stadium · Glendale, AZ |
| 14 | Sun Dec 13 | vs Commanders | L15-23 | 5-8 | .385 | State Farm Stadium · Glendale, AZ |
| 15 | Sun Dec 20 | at Cowboys | L33-41 | 5-9 | .357 | AT&T Stadium · Arlington, TX |
| 16 | Sat Dec 26 | atCardinals | W20-12 | 6-9 | .400 | State Farm Stadium · Glendale, AZ |
| 17 | Sun Jan 3 | vsSeahawks | L23-26 | 6-10 | .375 | State Farm Stadium · Glendale, AZ |
