| 1 | Sun Sep 8 | vs 49ers | L17-31 | - | 0-1 | .000 | Raymond James Stadium · Tampa, FL |
| 2 | Thu Sep 12 | atPanthers | W20-14 | - | 1-1 | .500 | Bank of America Stadium · Charlotte, NC |
| 3 | Sun Sep 22 | vsGiants | L31-32 | - | 1-2 | .333 | Raymond James Stadium · Tampa, FL |
| 4 | Sun Sep 29 | atRams | W55-40 | - | 2-2 | .500 | SoFi Stadium · Inglewood, CA |
| 5 | Sun Oct 6 | atSaints | L24-31 | - | 2-3 | .400 | Caesars Superdome · New Orleans, LA |
| 6 | Sun Oct 13 | vsPanthers | L26-37 | - | 2-4 | .333 | Tottenham Hotspur Stadium · London, England |
| --bye week-- |
| 8 | Sun Oct 27 | atTitans | L23-27 | - | 2-5 | .286 | Nissan Stadium · Nashville, TN |
| 9 | Sun Nov 3 | atSeahawks | L34-40 (OT) | - | 2-6 | .250 | Lumen Field · Seattle, WA |
| 10 | Sun Nov 10 | vsCardinals | W30-27 | - | 3-6 | .333 | Raymond James Stadium · Tampa, FL |
| 11 | Sun Nov 17 | vsSaints | L17-34 | - | 3-7 | .300 | Raymond James Stadium · Tampa, FL |
| 12 | Sun Nov 24 | atFalcons | W35-22 | - | 4-7 | .364 | Mercedes-Benz Stadium · Atlanta, GA |
| 13 | Sun Dec 1 | atJaguars | W28-11 | - | 5-7 | .417 | TIAA Bank Field · Jacksonville, FL |
| 14 | Sun Dec 8 | vsColts | W38-35 | - | 6-7 | .462 | Raymond James Stadium · Tampa, FL |
| 15 | Sun Dec 15 | atLions | W38-17 | - | 7-7 | .500 | Ford Field · Detroit, MI |
| 16 | Sat Dec 21 | vsTexans | L20-23 | - | 7-8 | .467 | Raymond James Stadium · Tampa, FL |
| 17 | Sun Dec 29 | vsFalcons | L22-28 (OT) | - | 7-9 | .438 | Raymond James Stadium · Tampa, FL |
