| 1 | Sun Sep 13 | at Saints | L23-34 | - | 0-1 | .000 | Caesars Superdome · New Orleans, LA |
| 2 | Sun Sep 20 | vsPanthers | W31-17 | - | 1-1 | .500 | Raymond James Stadium · Tampa, FL |
| 3 | Sun Sep 27 | atBroncos | W28-10 | - | 2-1 | .667 | Empower Field at Mile High · Denver, CO |
| 4 | Sun Oct 4 | vsChargers | W38-31 | - | 3-1 | .750 | Raymond James Stadium · Tampa, FL |
| 5 | Thu Oct 8 | atBears | L19-20 | - | 3-2 | .600 | Soldier Field · Chicago, IL |
| 6 | Sun Oct 18 | vsPackers | W38-10 | - | 4-2 | .667 | Raymond James Stadium · Tampa, FL |
| 7 | Sun Oct 25 | atRaiders | W45-20 | - | 5-2 | .714 | Allegiant Stadium · Las Vegas, NV |
| 8 | Mon Nov 2 | atGiants | W25-23 | - | 6-2 | .750 | MetLife Stadium · East Rutherford, NJ |
| 9 | Sun Nov 8 | vsSaints | L3-38 | - | 6-3 | .667 | Raymond James Stadium · Tampa, FL |
| 10 | Sun Nov 15 | atPanthers | W46-23 | - | 7-3 | .700 | Bank of America Stadium · Charlotte, NC |
| 11 | Mon Nov 23 | vsRams | L24-27 | - | 7-4 | .636 | Raymond James Stadium · Tampa, FL |
| 12 | Sun Nov 29 | vsChiefs | L24-27 | - | 7-5 | .583 | Raymond James Stadium · Tampa, FL |
| --bye week-- |
| 14 | Sun Dec 13 | vsVikings | W26-14 | - | 8-5 | .615 | Raymond James Stadium · Tampa, FL |
| 15 | Sun Dec 20 | atFalcons | W31-27 | - | 9-5 | .643 | Mercedes-Benz Stadium · Atlanta, GA |
| 16 | Sat Dec 26 | atLions | W47-7 | - | 10-5 | .667 | Ford Field · Detroit, MI |
| 17 | Sun Jan 3 | vsFalcons | W44-27 | - | 11-5 | .688 | Raymond James Stadium · Tampa, FL |
| WC | Sat Jan 9 | atCommanders | W31-23 | - | 11-5 | .688 | FedEx Field · North Englewood, MD |
| DIV | Sun Jan 17 | atSaints | W30-20 | - | 11-5 | .688 | Caesars Superdome · New Orleans, LA |
| CONF | Sun Jan 24 | atPackers | W31-26 | - | 11-5 | .688 | Lambeau Field · Green Bay, WI |
| SB | Sun Feb 7 | vsChiefs | W31-9 | - | 11-5 | .688 | Raymond James Stadium · Tampa, FL |
