| 1 | Sun Sep 12 | vs 49ers | L33-41 | 0-1 | .000 | Ford Field · Detroit, MI |
| 2 | Mon Sep 20 | atPackers | L17-35 | 0-2 | .000 | Lambeau Field · Green Bay, WI |
| 3 | Sun Sep 26 | vsRavens | L17-19 | 0-3 | .000 | Ford Field · Detroit, MI |
| 4 | Sun Oct 3 | atBears | L14-24 | 0-4 | .000 | Soldier Field · Chicago, IL |
| 5 | Sun Oct 10 | atVikings | L17-19 | 0-5 | .000 | U.S. Bank Stadium · Minneapolis, MN |
| 6 | Sun Oct 17 | vsBengals | L11-34 | 0-6 | .000 | Ford Field · Detroit, MI |
| 7 | Sun Oct 24 | atRams | L19-28 | 0-7 | .000 | SoFi Stadium · Inglewood, CA |
| 8 | Sun Oct 31 | vsEagles | L6-44 | 0-8 | .000 | Ford Field · Detroit, MI |
| --bye week-- |
| 10 | Sun Nov 14 | atSteelers | T16-16 (OT) | 0-8-1 | .056 | Acrisure Stadium · Pittsburgh, PA |
| 11 | Sun Nov 21 | atBrowns | L10-13 | 0-9-1 | .050 | FirstEnergy Stadium · Cleveland, OH |
| 12 | Thu Nov 25 | vsBears | L14-16 | 0-10-1 | .045 | Ford Field · Detroit, MI |
| 13 | Sun Dec 5 | vsVikings | W29-27 | 1-10-1 | .125 | Ford Field · Detroit, MI |
| 14 | Sun Dec 12 | atBroncos | L10-38 | 1-11-1 | .115 | Empower Field at Mile High · Denver, CO |
| 15 | Sun Dec 19 | vsCardinals | W30-12 | 2-11-1 | .179 | Ford Field · Detroit, MI |
| 16 | Sun Dec 26 | atFalcons | L16-20 | 2-12-1 | .167 | Mercedes-Benz Stadium · Atlanta, GA |
| 17 | Sun Jan 2 | atSeahawks | L29-51 | 2-13-1 | .156 | Lumen Field · Seattle, WA |
| 18 | Sun Jan 9 | vsPackers | W37-30 | 3-13-1 | .206 | Ford Field · Detroit, MI |
