| 5 | Sun Oct 5 | at Bengals | 4:25 PM | 2-2 | .500 | Paycor Stadium · Cincinnati, OH |
| 6 | Sun Oct 12 | atChiefs | 8:20 PM | 2-2 | .500 | Arrowhead Stadium · Kansas City, MO |
| 7 | Mon Oct 20 | vsBuccaneers | 7:00 PM | 3-1 | .750 | Ford Field · Detroit, MI |
| --bye week-- |
| 9 | Sun Nov 2 | vsVikings | 1:00 PM | 2-2 | .500 | Ford Field · Detroit, MI |
| 10 | Sun Nov 9 | atCommanders | 4:25 PM | 2-2 | .500 | FedEx Field · North Englewood, MD |
| 11 | Sun Nov 16 | atEagles | 8:20 PM | 4-0 | 1.000 | Lincoln Financial Field · Philadelphia, PA |
| 12 | Sun Nov 23 | vsGiants | 1:00 PM | 1-3 | .250 | Ford Field · Detroit, MI |
| 13 | Thu Nov 27 | vsPackers | 1:00 PM | 2-1-1 | .667 | Ford Field · Detroit, MI |
| 14 | Thu Dec 4 | vsCowboys | 8:15 PM | 1-2-1 | .333 | Ford Field · Detroit, MI |
| 15 | Sun Dec 14 | atRams | 4:25 PM | 3-1 | .750 | SoFi Stadium · Inglewood, CA |
| 16 | Sun Dec 21 | vsSteelers | 4:25 PM | 3-1 | .750 | Ford Field · Detroit, MI |
| 17 | Thu Dec 25 | atVikings | 4:30 PM | 2-2 | .500 | U.S. Bank Stadium · Minneapolis, MN |
