| 1 | Sun Sep 11 | vs Eagles | L35-38 | 0-1 | .000 | Ford Field · Detroit, MI |
| 2 | Sun Sep 18 | vs Commanders | W36-27 | 1-1 | .500 | Ford Field · Detroit, MI |
| 3 | Sun Sep 25 | at Vikings | L24-28 | 1-2 | .333 | U.S. Bank Stadium · Minneapolis, MN |
| 4 | Sun Oct 2 | vs Seahawks | L45-48 | 1-3 | .250 | Ford Field · Detroit, MI |
| 5 | Sun Oct 9 | at Patriots | L0-29 | 1-4 | .200 | Gillette Stadium · Foxborough, MA |
| 6 | -- BYE WEEK -- |
| 7 | Sun Oct 23 | at Cowboys | L6-24 | 1-5 | .167 | AT&T Stadium · Arlington, TX |
| 8 | Sun Oct 30 | vs Dolphins | L27-31 | 1-6 | .143 | Ford Field · Detroit, MI |
| 9 | Sun Nov 6 | vs Packers | W15-9 | 2-6 | .250 | Ford Field · Detroit, MI |
| 10 | Sun Nov 13 | at Bears | W31-30 | 3-6 | .333 | Soldier Field · Chicago, IL |
| 11 | Sun Nov 20 | at Giants | W31-18 | 4-6 | .400 | MetLife Stadium · East Rutherford, NJ |
| 12 | Thu Nov 24 | vs Bills | L25-28 | 4-7 | .364 | Ford Field · Detroit, MI |
| 13 | Sun Dec 4 | vs Jaguars | W40-14 | 5-7 | .417 | Ford Field · Detroit, MI |
| 14 | Sun Dec 11 | vsVikings | W34-23 | 6-7 | .462 | Ford Field · Detroit, MI |
| 15 | Sun Dec 18 | at Jets | W20-17 | 7-7 | .500 | MetLife Stadium · East Rutherford, NJ |
| 16 | Sat Dec 24 | at Panthers | L23-37 | 7-8 | .467 | Bank of America Stadium · Charlotte, NC |
| 17 | Sun Jan 1 | vsBears | W41-10 | 8-8 | .500 | Ford Field · Detroit, MI |
| 18 | Sun Jan 8 | atPackers | W20-16 | 9-8 | .529 | Lambeau Field · Green Bay, WI |
