| 1 | Sun Sep 12 | vs Vikings | W27-24 (OT) | 1-0 | 1.000 | Paycor Stadium · Cincinnati, OH |
| 2 | Sun Sep 19 | at Bears | L17-20 | 1-1 | .500 | Soldier Field · Chicago, IL |
| 3 | Sun Sep 26 | at Steelers | W24-10 | 2-1 | .667 | Acrisure Stadium · Pittsburgh, PA |
| 4 | Thu Sep 30 | vs Jaguars | W24-21 | 3-1 | .750 | Paycor Stadium · Cincinnati, OH |
| 5 | Sun Oct 10 | vs Packers | L22-25 (OT) | 3-2 | .600 | Paycor Stadium · Cincinnati, OH |
| 6 | Sun Oct 17 | at Lions | W34-11 | 4-2 | .667 | Ford Field · Detroit, MI |
| 7 | Sun Oct 24 | at Ravens | W41-17 | 5-2 | .714 | M&T Bank Stadium · Baltimore, MD |
| 8 | Sun Oct 31 | at Jets | L31-34 | 5-3 | .625 | MetLife Stadium · East Rutherford, NJ |
| 9 | Sun Nov 7 | vs Browns | L16-41 | 5-4 | .556 | Paycor Stadium · Cincinnati, OH |
| 10 | -- BYE WEEK -- |
| 11 | Sun Nov 21 | at Raiders | W32-13 | 6-4 | .600 | Allegiant Stadium · Las Vegas, NV |
| 12 | Sun Nov 28 | vsSteelers | W41-10 | 7-4 | .636 | Paycor Stadium · Cincinnati, OH |
| 13 | Sun Dec 5 | vs Chargers | L22-41 | 7-5 | .583 | Paycor Stadium · Cincinnati, OH |
| 14 | Sun Dec 12 | vs 49ers | L23-26 (OT) | 7-6 | .538 | Paycor Stadium · Cincinnati, OH |
| 15 | Sun Dec 19 | at Broncos | W15-10 | 8-6 | .571 | Empower Field at Mile High · Denver, CO |
| 16 | Sun Dec 26 | vsRavens | W41-21 | 9-6 | .600 | Paycor Stadium · Cincinnati, OH |
| 17 | Sun Jan 2 | vs Chiefs | W34-31 | 10-6 | .625 | Paycor Stadium · Cincinnati, OH |
| 18 | Sun Jan 9 | atBrowns | L16-21 | 10-7 | .588 | FirstEnergy Stadium · Cleveland, OH |
| WC | Sat Jan 15 | vsRaiders | W26-19 | 10-7 | .588 | Paycor Stadium · Cincinnati, OH |
| DIV | Sat Jan 22 | at Titans | W19-16 | 10-7 | .588 | Nissan Stadium · Nashville, TN |
| CONF | Sun Jan 30 | atChiefs | W27-24 (OT) | 10-7 | .588 | Arrowhead Stadium · Kansas City, MO |
| SB | Sun Feb 13 | vs Rams | L20-23 | 10-7 | .588 | SoFi Stadium · Inglewood, CA |
